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Zapping the brain to boost motivation in seniors

NCT ID NCT05232877

Symptom relief Sponsor: Centre Hospitalier Universitaire de Nice Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a gentle electrical brain stimulation technique called tDCS, combined with cognitive training on a tablet, can reduce apathy in older adults with mild cognitive impairment. Apathy is a lack of motivation and interest that can affect daily life. The trial involves 27 participants aged 65 and older who will receive either real tDCS plus training or a sham (fake) version over 12 sessions in 4 weeks. The goal is to see if this combination can improve emotional engagement, initiative, and interest.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
transcranial direct current stimulation (tDCS) combined with cognitive training
What this could lead to
If it works, this could offer a non-drug way to ease apathy in older adults with mild cognitive problems, improving motivation and daily function.
What could go wrong
This is a small, early-phase study with only 27 participants, so results may not apply widely. The effect of tDCS can be subtle, and the sham group may also improve.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

27 people

The number who actually took part.

Started

Apr 2022

Expected to finish

Jun 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 65 years * Subject consulting in one of the investigating centers * Clinical diagnosis of Minor Neurocognitive Disorder according to DSM 5 criteria (APA, 2013) * Apathetic syndrome defined according to the Diagnostic Criteria for Apathy (Miller \& al., 2021) * Subject who can read and write French * Subjects who are beneficiaries of a social security plan * Signature of free and informed consent Exclusion Criteria: * Current clinical diagnosis of a depressive episode characterized by DSM 5 criteria (APA, 2013) * Known diagnosis of schizophrenia, bipolar disorder, substance abuse or dependence * Significant sensory or motor impairment * Subject under guardianship, conservatorship, or conservatorship * Active smoking or smoking cessation of less than one year * Contraindications to the practice of tDCS: history of intracranial hypertension, neurosurgery, metallic implant at the cephalic level, pacemaker * Unbalanced epilepsy * Severe somatic disease not stabilized * Previous use of tDCS (problem of maintaining the integrity of the blinding procedure) * Scalp skin disease * Concurrent participation in another drug research study or any other study that may interfere with study results

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Conditions

The condition(s) this trial relates to.

cognitive disorder Lethargy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

APATHY Neurocognitive disorders

Contacts and locations

Locations

  • Centre Memoire Ressources et Recherche, CHU de Nice

    Nice, 06000, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.