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Electric brain stimulation tested for memory loss in seniors

NCT ID NCT05998031

Knowledge-focused Sponsor: University of Florida Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether a mild electrical current applied to the scalp (tDCS) can improve working memory in older adults with mild cognitive impairment (MCI). Researchers will compare the effects of real tDCS versus a sham (fake) version in 110 participants aged 60-95. The goal is to understand how tDCS affects brain activity and memory, not to provide a treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
transcranial direct current stimulation (tDCS)
What this could lead to
If it works, this could point toward a non-drug way to boost memory in people with mild cognitive impairment.
What could go wrong
This is an early mechanistic study, not a treatment trial. It may not show clear memory benefits, and any effects might be small or temporary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 110 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2024

Expected to finish

Nov 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

60 to 95 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria * Age 60-95 years * Montreal Cognitive Assessment (MoCA) score 18 and above (scores will be adjusted for education) * Able to receive electrical stimulation * Ability to comprehend conversational voices * Adequate motor capacity to operate computer mouse and click-button in-scanner * Ability to participate in the intervention and attend training sessions Exclusion Criteria * Failure to provide informed consent * Contraindications to MRI recording (e.g., any kind of ferrous metallic stents or ferrous metal objects in the body, heart valve prosthesis, or other metal implants, claustrophobia, neurostimulation system, defibrillator, pacemaker, or other implanted device) * Left-handed, or left hand dominant * History of neurological, seizures, and psychiatric disorders, traumatic brain injury, incidence of stroke involving large vessel * Terminal illness with life expectancy less than 12 months, as determined by physician * Brain tumor or malformation or any foreign body known or previously identified in brain * Cancer in active treatment, besides skin cancer * Currently on GABAergic or glutamatergic medications, or on calcium or sodium channel blockers, which alter or block the ability of tDCS to facilitate tissue excitability * Unable to communicate because of severe hearing loss or speech disorder * Severe sensory impairment * Inability to communicate in English * Severe visual impairment, which would preclude completion of the assessment and/or intervention * No physical impairment precluding motor response or lying still for an hour in the scanner that could confound study findings * Moderate-to-severe depressive symptoms as defined by scoring 10 or above on the Geriatric Depression Scale (GDS)

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cognitive decline Cognitive impairment

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    1 site. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • University of Florida

    RECRUITING

    Gainesville, Florida, 32610, United States

    Contact Email: •••••@•••••

    Contact Email: •••••@•••••

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