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Food supplements that curb appetite show promise in small study

NCT ID NCT07448519

Symptom relief Sponsor: Queen Mary University of London Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether special food supplement capsules that release nutrients in the lower gut can increase appetite-regulating hormones and reduce food intake. Twenty adults with obesity took either the active supplement or a placebo on two separate days. The supplement increased levels of hormones that signal fullness and reduced calorie intake at lunch in female participants.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Colonic-delivered DIM and Perilla oil
What this could lead to
If it works, this could lead to a natural supplement that helps control appetite and reduce calorie intake in people with obesity.
What could go wrong
This was a small, early study with only 20 participants, so results may not apply to everyone. The supplement only showed effects in female volunteers, and long-term safety and effectiveness are not yet known.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

20 people

The number who actually took part.

Started

Jun 2023

Finished

Aug 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Obese but otherwise healthy volunteers aged between 18 and 60 years, of either sex * Body Mass Index (BMI) of 30-40 kg/m² * Agreement to eat the scheduled meals * Ability to understand the study information sheet and instructions in English, and able to provide informed consent Exclusion Criteria: * Not meeting any of the inclusion criteria above * Major gut surgery involving removal of any part of the gastrointestinal tract * Known major bowel disease * Currently taking medication for diabetes (Type 1 or Type 2) * Currently taking medication for weight loss

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Appetite regulation Obesity & overweight

Contacts and locations

Locations

  • Wingate Institute of Neurogastroenterology

    London, E1 2AJ, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.