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Nerve blocks may offer better pain relief for appendicitis patients in the ER

NCT ID NCT06808087

Symptom relief Sponsor: Ankara City Hospital Bilkent Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compared two types of nerve blocks (TAP and ESPB) to standard pain medication (tramadol) for people with acute appendicitis in the emergency department. The goal was to see if these blocks could reduce pain before surgery and lower the need for opioids. The trial included 96 adults and was completed at a single hospital in Turkey.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
nerve block (TAP block or ESPB block)
What this could lead to
If successful, this could show that nerve blocks are a better way to manage appendicitis pain in the ER, possibly reducing the need for strong painkillers like opioids.
What could go wrong
This is a small, completed study with only 96 participants. The results may not apply to all patients, and nerve blocks carry risks like infection or allergic reaction.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

96 people

The number who actually took part.

Started

May 2024

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

From the date of ethics committee approval, patients diagnosed with acute appendicitis in the emergency department and determined to undergo definitive surgery following general surgical consultation: patients with suspected acute appendicitis based on history, physical examination, laboratory tests, and Alvarado score calculation, and confirmed by ultrasound (USG) and/or contrast/non-contrast abdominal CT scans.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 18 years and older * Patients who provide written consent Exclusion Criteria: * Patients with abdominal wall anatomical abnormalities * Patients with known local anesthetic allergies * Patients with a BMI \>30 * Patients weighing less than 45 kg * Patients with coagulopathy * Patients with opioid, alcohol, or substance dependence * Patients with skin infections at the site of local anesthetic administration * Pregnant or breastfeeding patients * Hemodynamically unstable patients * Patients with liver or kidney failure * Patients with chronic pain conditions * Patients who have difficulty cooperating or have language barriers * Patients who do not provide written consent * Patients under 18 years of age

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Conditions

The condition(s) this trial relates to.

agnosia appendicitis Emergencies

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute appendicitis

Contacts and locations

Locations

  • Ankara City Hospital

    Ankara, Yenimahalle, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.