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New drug aims to cut opioid use after common knee surgery

NCT ID NCT07355166

Symptom relief Sponsor: University of California, Los Angeles Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This study tests whether a new painkiller called suzetrigine can help people use fewer opioids after ACL surgery while still controlling pain. About 140 participants will receive either suzetrigine or standard opioid-based pain care and report their pain, opioid use, and side effects for one week. The goal is to see if suzetrigine can provide effective pain relief with less reliance on opioids.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Suzetrigine (Journavx)
What this could lead to
If successful, this could offer a way to manage post-surgery pain with fewer opioids, reducing addiction risk.
What could go wrong
This is a small, early-phase trial focused on a specific surgery. Results may not apply to other procedures, and suzetrigine may not control pain as well as opioids.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 140 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients undergoing reconstruction of primary ACL tear Exclusion Criteria: * Concurrent ligamentous injuries requiring surgical intervention * Full thickness cartilage injury requiring discrete surgical intervention * Chronic opioid use * Significant hepatic disease (Child/Pugh C) * Women who are pregnant or breastfeeding * Women of childbearing age using hormonal contraceptives containing progestins other than levonorgestrel and norethindrone * Allergies or intolerance to any study medications * Inability to complete ePROs (due to literacy or infirmity)

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postoperative pain management

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

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