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Knife or stretch? trial to settle best fix for trapped arm nerve

NCT ID NCT07484100

Symptom relief Sponsor: Tampere University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This trial compares surgery to physiotherapy for people with persistent median nerve compression in the upper arm. 160 adults will be randomly assigned to either a nerve release operation or guided stretching exercises. The main goal is to see which treatment leads to better symptom relief after 6 months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
surgery (proximal median nerve release) and physiotherapy (nerve stretching exercises)
What this could lead to
If surgery proves more effective, it could become a standard treatment for stubborn median nerve compression in the arm.
What could go wrong
This is a small, early-stage trial that hasn't started yet. Surgery carries typical risks like infection or nerve damage, and the results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 160 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Mar 2026

An estimate. Start dates often move.

Expected to finish

Jul 2041

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Clinically diagnosed PMNC 2. If the patient has clinically and electrodiagnostically confirmed carpal tunnel syndrome, at least 6 months must have passed since surgical treatment 3. Age 18 or over 4. Ability to understand Finnish 5. Ability to complete electronic questionnaires independently 6. Willingness to participate in research and follow research instructions 7. Provision of informed consent from the participant Exclusion Criteria: 1. Nerve root disorder findings in ENMG 2. Thoracic outlet syndrome, TOS 3. Other neurological condition that causes upper limb symptoms such as MS, previous nerve injury 4. Active rheumatoid arthritis or any other active inflammatory joint disease that affects hand function 5. Significant compression symptoms of another peripheral nerve in association with PMNC 6. Other upper extremity operation performed less than 6 months ago 7. Another disease or condition that accounts for most of the patient's symptoms 8. Other known reasons that may prevent participation or implementation of treatment during the study

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Conditions

The condition(s) this trial relates to.

median nerve neuropathy nerve compression syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Carpal tunnel surgery Median nerve compression Median nerve entrapment

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Seinäjoki Central Hospital

    Seinäjoki, Finland

  • Tampere University Hospital

    Tampere, Finland

More trials for these conditions

Other studies related to the condition(s) this trial covers.