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Could a stressed brain speed up Alzheimer's? new study investigates

NCT ID NCT05521919

Knowledge-focused Sponsor: University of Southern California Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether a brief stressful event can quickly change levels of certain proteins in the blood linked to Alzheimer's disease. Researchers measured these proteins in 38 healthy adults before and after a stress task. The goal is to understand how stress might influence Alzheimer's risk.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could help explain how stress might increase Alzheimer's risk, potentially guiding future prevention strategies.
What could go wrong
This is a small, early-stage study with only 38 healthy adults, so results may not apply to everyone. It measures short-term changes, not long-term disease outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

38 people

The number who actually took part.

Started

Dec 2023

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Healthy adult weighing at least 110 pounds * No chronic conditions or illness * Taking no medications or drugs that might alter the stress response (e.g., corticosteroids, beta-blockers, and others) * Not using any hormone-containing medication (e.g., hormonal contraceptives, hormone replacement, etc.) * No contraindications for cold pressor test exposure (high blood pressure, heart disease, dysrhythmia, peripheral vascular disease, any other cardiovascular disorder, diabetes, vasculitis, lupus, tingling or numbness in the hands and/or feet, cryoglobulinemia, and Reynaud's phenomenon) * No history of fainting during blood draws * No phobia of having their blood drawn * No general history of fainting or seizures * Not currently diagnosed with a mood disorder (e.g., major depressive disorder) * Not pregnant in the past 12 months * Not lactating in the past 12 months * Not trying to become pregnant if premenopausal * Experienced natural menopause if postmenopausal * Be non-smokers * Be fluent in English Exclusion Criteria: \- Unwilling to be filmed during the stress task OR unwilling to sign the waiver allowing their filmed responses to be used in scientific presentations

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Conditions

The condition(s) this trial relates to.

Fractures, Stress Plaque, Amyloid

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Stress physiology Stress reaction

Contacts and locations

Locations

  • University of Southern California

    Los Angeles, California, 90089, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.