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Tiny needle particles could make skin creams work better

NCT ID NCT06004973

Knowledge-focused Sponsor: Emory University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested how to best apply STAR particles—tiny particles covered with microneedles—to healthy skin. The goal was to find the right pressure and rubbing method to create small punctures that could help future topical medications work better. Twenty healthy adults took part, and researchers measured skin water loss and pain to determine the best application method.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
STAR particles (microneedle-covered particles in aloe vera gel)
What this could lead to
If successful, this could help develop better ways to deliver topical medications through the skin.
What could go wrong
This is a very early, small pilot study in healthy volunteers with no active drug. Results may not apply to people with skin conditions or to actual drug delivery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

20 people

The number who actually took part.

Started

Feb 2024

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 39 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult, 18 - 39 years of age * In good general health as determined by a medical history * Willing and able to provide informed consent and follow all study requirements * Not pregnant and does not desire to become pregnant in the subsequent two months Exclusion Criteria: * Has a known allergy or sensitivity to aloe vera or alumina * Has any skin disorders or skin allergies * Has any medical condition that may affect skin or skin sensation * Has abnormal (e.g., tattooed) skin at forearms * Has known neurological condition affecting sensory function or perception of pain * Has inflammatory bowel disease * Has applied skin ointment or cream to forearms in the previous 24 hours * Has a major congenital or chromosomal abnormality known to affect the skin * Has taken pain medication in the last 24 hours * Is currently participating in another interventional clinical trial * Has previously participated in a STAR particle interventional clinical trial * Is pregnant or wishing to be pregnant * Has any condition (social or medical), which in the opinion of the investigator would make study participation unsafe, would interfere with adherence to the clinical study requirements, or would complicate data interpretation

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy

Contacts and locations

Locations

  • Emory Children's Center

    Atlanta, Georgia, 30322, United States

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