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Better scans could help measure spine fusion in ankylosing spondylitis

NCT ID NCT00085995

Knowledge-focused Sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether CT scans are better than regular X-rays for measuring how the spine stiffens and fuses in people with ankylosing spondylitis. Researchers will follow 63 adults over 4 years, using scans, blood tests, and flexibility measurements. The goal is to find a more precise way to track disease progression, which could help test future treatments.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could lead to better ways to measure spinal fusion, helping doctors evaluate new treatments for ankylosing spondylitis more accurately.
What could go wrong
This is an observational study, not a treatment trial. It only tests imaging methods, so it won't directly improve symptoms or slow disease progression.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

63 people

The number who actually took part.

Started

Dec 2004

Finished

Feb 2021

Lead sponsor

A government research agency

The lead sponsor is the US National Institutes of Health.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

clinical sample

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

* A. LONGITUDINAL STUDY PROTOCOL: Fifty-five patients will be studied. INCLUSION CRITERIA: 1. Age 18 years or older 2. Diagnosis of AS by the modified New York criteria 3. Lumbar spine BASRI score of 0, 1, 2, or 3 We will aim to recruit at least 6 patients in each of the following BASRI lumbar spine categories: * 0 or 1 (normal or suspicious changes) * 2 (erosions, sclerosis or squaring with or without syndesmophytes or 2 or fewer vertebrae) * 3 (syndesmophytes on 3 or more vertebrae with fusion of at most 2 vertebrae) EXCLUSION CRITERIA: 1. Inability to provide informed consent. 2. BASRI lumbar spine score of 4 (complete fusion; 12) 3. Contraindication to MRI scanning based on the NMR Center MRI Safety Screening Questionnaire or size or weight limitations of the scanner. 4. History of allergic reactions to gadolinium-DPTA contrast used for MRI 5. Anticipated unavailability for follow-up over 2 years 6. Pregnancy 7. Onset of AS at age 16 or younger 8. Spondyloarthropathy other than AS 9. Severe scoliosis or other spinal malalignment that would complicate scan interpretation B. CROSS-SECTIONAL (RELIABILITY) STUDY PROTOCOL Up to 35 patients will be studied. INCLUSION CRITERIA: 1. Age 18 years or older 2. Diagnosis of AS by the modified New York criteria (5) EXCLUSION CRITERIA: 1. Inability to provide informed consent 2. BASRI lumbar spine score of 4 (complete fusion)\<TAB\> 3. Pregnancy 4. Onset of AS at age 16 or younger 5. Spondyloarthropathy other than AS 6. Severe scoliosis or other spinal malalignment that would complicate scan interpretation

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Conditions

The condition(s) this trial relates to.

ankylosing spondylitis Spondylarthritis Spondylarthropathies

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ankylosing spondylitis

Contacts and locations

Locations

  • National Institutes of Health Clinical Center

    Bethesda, Maryland, 20892, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.