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Wrist injection may tame overactive nerves, early study hints

NCT ID NCT07429292

Knowledge-focused Sponsor: Duke University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study will test whether a small injection of lidocaine around the radial artery in the wrist can temporarily reduce sympathetic nerve activity in 20 healthy volunteers. Researchers will measure blood flow and hand temperature before and after the injection, using cold water to trigger a stress response. The goal is to see if this simple block can dampen the body's 'fight or flight' signals in the hand.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
lidocaine
What this could lead to
If successful, this could provide a new way to study and potentially treat conditions involving overactive sympathetic nerves, like Raynaud's phenomenon.
What could go wrong
This is a very small, early-phase study in healthy people, not patients. The effect may be temporary or not translate to real-world treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Apr 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18-50 years * ASA physical status I-II * Able to understand and provide informed consent * Able to comply with study procedures and follow-up * Two hands with 5 intact digits and no significant upper extremity injury Exclusion Criteria: * Allergy to lidocaine or similar anesthetics * Allergy to adhesives or ultrasound gel * Neuromuscular, autonomic, or major vascular disorders affecting upper extremities * Peripheral neuropathy * Raynaud's phenomenon or digital ischemia * Coagulopathy or anticoagulation * Active skin infection near block site * Pregnancy * BMI \> 35 kg/m² * Inability to tolerate cold exposure * Any condition interfering with study conduct

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy volunteers Sympathetic activity

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Duke University Medical Center

    Durham, North Carolina, 27710, United States

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