Could a common drug ease painful jaw clicking?
NCT ID NCT07487675
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether adding the drug sodium valproate to a standard jaw-washing procedure can lower inflammation in people with a painful jaw joint condition. Ten female participants with jaw clicking and pain will receive the drug intravenously during the procedure. Researchers will measure changes in an inflammatory protein called IL-6 to see if the combination works better than the procedure alone.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- sodium valproate
- What this could lead to
- If it works, this could point toward a new way to reduce inflammation and pain in jaw joint disorders.
- What could go wrong
- This is a very small early-phase trial with only 10 participants, so results may not apply widely. The drug's effect on inflammation is still uncertain.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
-
10 people
The number who actually took part.
- Started
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Sep 2024
- Expected to finish
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May 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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17 to 35 years
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Female patients between the ages of 17 and 35 years. * Clinical and radiographic diagnosis (via MRI) of TMJ anterior disc displacement with reduction (ADDWR). * Patients who failed to respond to conservative treatment (e.g., medication, splint therapy, or physical therapy) for more than three months. * Presence of clinical symptoms including joint pain, clicking sounds, or limited mouth opening. Exclusion Criteria: * History of previous TMJ surgery or arthrocentesis. * Presence of systemic inflammatory diseases or metabolic bone diseases (e.g., rheumatoid arthritis). * Evidence of bony changes in the TMJ (e.g., osteoarthritis or ankylosis). * patients with history of systemic immune disease * Patients with TMJ neoplastic changes. * Patients with history of recent facial trauma * Patients with high risk of hemorrhage * Patients with prosthetic joint replacement * Patients with allergic to any component of the injectable solution.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Tanta University
Tanta, Gharbia Governorate, 31773, Egypt