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Can baking soda save lives in the ICU? new trial investigates

NCT ID NCT02476253

Disease control Sponsor: University Hospital, Montpellier Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether giving sodium bicarbonate (a common buffer) to critically ill patients with severe metabolic acidosis helps them survive and recover. 400 ICU patients with low blood pH and high lactate were randomly assigned to receive either sodium bicarbonate or no buffer. The main goal was to see if it reduced death or organ failure by day 28.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Sodium Bicarbonate
What this could lead to
If it works, this could provide a simple, low-cost way to improve survival and reduce organ failure in ICU patients with severe acidosis.
What could go wrong
This is a completed phase 3 trial, but sodium bicarbonate has been debated for decades and may not improve outcomes. It could also cause side effects like fluid overload or electrolyte imbalances.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

400 people

The number who actually took part.

Started

May 2015

Finished

May 2017

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age of 18 yo or above, * Critically ill patient with a SOFA score of 4 or above, * Lactatemia of 2mmol/l or above, with pH of 7.20 or below and PaCO2 of 45mmHg or below and bicarbonatemia of 20mmol/l or below Exclusion Criteria: * Administration of Sodium Bicarbonate 24 hours before inclusion * Single respiratory disorder (PaCO2 \> 50 mmHg, Bicarbonatemia equal or higher than (PaCO2-40)/10 + 24 * Acute diarrhea, ileostomy or biliary drainage * Stage IV kidney failure or chronic dialysis * Tubular acidosis, ketoacidosis, high anion gap acids poisoning (PEG, aspirin, methanol) * PaCO2 equal to 45mmHg or above and spontaneous breathing, pregnancy, protected patients, moribund patient (life expectancy of 48h or below)

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Conditions

The condition(s) this trial relates to.

Acidosis metabolic acidosis Shock

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Metabolic acidosis

Contacts and locations

Locations

  • DAR St Eloi

    Montpellier, 34000, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.