Could your nose warn of a rare heart disease?
NCT ID NCT04661800
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study checked how common smell and taste problems are in 51 people with cardiac amyloidosis, a rare disease where abnormal proteins build up in the heart. Researchers used a simple smell test called Sniffin' Sticks to measure these senses. The goal was to see if these issues could help spot the disease earlier, before heart symptoms get serious.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If smell and taste loss are common early signs, doctors might use them to catch cardiac amyloidosis sooner.
- What could go wrong
- This is a small, completed observational study—it only measures the problem, not a treatment. Results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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51 people
The number who actually took part.
- Started
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Mar 2021
- Finished
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Sep 2023
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age\>18 years * Affiliated with Social Security * Patient who was informed of the study and signed a free and informed consent * Patients diagnosed with AC Exclusion Criteria: * \- Refusal to participate in the study * Patient who does not speak or understand French * History of chronic rhino sinusitis with or without polyps * A history of counter-indicating the completion of nasal endoscopy (repeated epistaxis, obstructive naso-sinusal tumors, choanal imperforation) * History of major craniofacial trauma resulting in loss of smell * Known history of Parkinson's disease or Alzheimer's disease * Antecedent of ENT radiotherapy * History of chemotherapy * Patient under guardianship, curatorship or legal protection * Patient on AME * Pregnant or lactating women
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Assistance Publique Hôpitaux de Paris - CHU HENRI MONDOR
Créteil, 94010, France
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Other studies related to the condition(s) this trial covers.
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