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Sugar alcohol drink may reveal hidden gut sensitivity

NCT ID NCT07817706

Diagnosis Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 14, 2026 · Last updated Sep 15, 2026 · Updated 1 time

Summary

Mayo Clinic researchers are testing whether drinking mannitol, a sugar alcohol, can safely measure how sensitive the small intestine is. About 20 healthy adults without gut disorders will swallow one of three mannitol solutions at different concentrations, each tagged with a tiny radioactive tracer. Scans track where the liquid goes and how quickly, while participants rate symptoms like pain, bloating, and nausea. The goal is to find the concentration that reliably produces a range of responses, setting a normal benchmark for future studies.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
mannitol, a sugar alcohol solution given at three different concentrations
What this could lead to
If it works, this could give doctors a simple, noninvasive way to measure small bowel sensitivity and help explain hard-to-diagnose gut symptoms.
What could go wrong
This is a small, early study in healthy people, so the results may not apply to patients with gut-brain disorders. The test involves radiation exposure and may not reliably provoke or measure symptoms.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * No current gastrointestinal symptoms * No prior history of GI disorders, in particular DGBIs * Ability to provide informed consent * Ability to participate in study procedures * Absence of other diseases (structural or metabolic) which could interfere with interpretation of the study results * For females, must not be pregnant or lactating due to radiation exposure. * Stable doses of thyroid replacement, estrogen replacement, low-dose aspirin for cardioprotection, and birth control are permissible. Exclusion Criteria * Subjects on any medications that impact transit or integrity of small bowel mucosal barrier (e.g. chronic NSAIDS) of the GI tract will be excluded. * Patients with prior bowel surgery (not including appendectomy and cholecystectomy) * Patients who may have altered sensation (central sensitization or conditions that may induce bowel hyperalgesia) based on PI review of medical history (ie, fibromyalgia, endometriosis, chronic pelvic pain)

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Disorders of gut brain interaction

How to take part

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  2. The official record

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    Open the record ↗

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Contacts and locations

Locations

  • Mayo Clinic

    RECRUITING

    Rochester, Minnesota, 55905, United States

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