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New combo therapy aims to tackle tough lung cancer

NCT ID NCT07175220

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial is testing whether combining the experimental drug SHR2554 with other anti-tumor treatments can safely shrink tumors in people with advanced non-small cell lung cancer that cannot be removed by surgery. About 200 participants will receive one of three drug combinations over 21-day cycles. The study focuses on safety and how well the tumors respond, with the hope of finding a new treatment option for this serious disease.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
SHR2554 tablets combined with other anti-tumor drugs (SHR-A2102, Adabelimumab, or SHR-1701)
What this could lead to
If successful, this could point toward a new combination treatment option for people with advanced non-small cell lung cancer that is not curable but may help control the disease.
What could go wrong
This is an early-phase (Phase 2) trial with only 200 participants, so results may not apply to everyone. The combinations may cause side effects or fail to shrink tumors as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2025

Expected to finish

Oct 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age range of 18-75 years old (including both ends), gender not limited; 2. Patients with locally advanced unresectable or metastatic non-small cell lung cancer diagnosed by pathology 3. ECOG score is 0 or 1 4. Expected survival period ≥ 12 weeks 5. Has a good level of organ function 6. Patients voluntarily joined the study and signed informed consent Exclusion Criteria: 1. Having difficulty swallowing or malabsorption syndrome or any other uncontrolled gastrointestinal disease (such as nausea, diarrhea, or vomiting), having undergone gastrectomy or gastric banding surgery, etc 2. Symptomatic or active central nervous system tumor metastasis 3. Previously or simultaneously suffering from other malignant tumors 4. Spinal cord compression that cannot be cured by surgery and/or radiotherapy 5. Accompanied by uncontrolled tumor related pain 6. Plan to receive any other anti-tumor treatment during this trial period 7. Receive other anti-tumor treatments within 4 weeks before the first medication 8. Having undergone major surgeries other than diagnosis or biopsy within 28 days prior to the first administration 9. Currently participating in other clinical studies or taking medication for the first time less than 4 weeks after the end of the previous clinical study 10. Moderate to severe pleural effusion with clinical symptoms 11. Individuals with active pulmonary tuberculosis infection within one year prior to the first use of medication 12. Subjects who have experienced severe infections within 30 days prior to their first medication use 13. Administer attenuated live vaccine within 30 days before the first use of medication. 14. History of immunodeficiency 15. Suffering from poorly controlled or severe cardiovascular and cerebrovascular diseases 16. History of interstitial pneumonia/non infectious pneumonia requiring hormone therapy in the past 17. AE caused by previous anti-tumor treatment has not recovered to CTCAE v5.0 level evaluation ≤ 1 18. Untreated active hepatitis 19. Female participants who are pregnant, breastfeeding, or planning to become pregnant during the study period. 20. There are other serious physical or mental illnesses or laboratory abnormalities present

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Sun Yat-sen University Cancer Center

    RECRUITING

    Guangzhou, Guangdong, 510060, China

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