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New drug cocktail aims to shrink lung tumors

NCT ID NCT07241767

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial tests an experimental drug called FH-006 combined with other cancer treatments in 200 people with advanced non-small cell lung cancer. The goal is to see if the combination is safe and can shrink tumors. Researchers will also determine the best dose for future studies.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
FH-006 (an experimental drug) combined with other anti-tumor therapies
What this could lead to
If successful, this could point toward a new combination treatment for advanced lung cancer.
What could go wrong
This is an early phase 2 trial, so the drug may not work or could cause side effects. Results may not apply to all lung cancer patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2025

Expected to finish

Nov 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age range: 18-75 years old (including both ends), gender is not limited. 2. Subjects with locally advanced or metastatic non-small cell lung cancer confirmed by histology or cytology as unsuitable for radical surgery or radiotherapy treatment 3. ECOG score is 0 or 1 4. Expected survival period ≥ 12 weeks 5. According to the RECIST v1.1 standard, there must be at least one measurable lesion. 6. Good level of organ function 7. The patient voluntarily joined this study and signed informed consent 8. Left ventricular ejection fraction (LVEF) ≥ 50% Exclusion Criteria: 1. Suffering from other malignant tumors within the past 5 years 2. Subjects with active central nervous system (CNS) tumor metastasis, a history of meningeal metastasis, or current meningeal metastasis 3. Patients with uncontrollable tumor related pain 4. Has serious cardiovascular and cerebrovascular diseases 5. Significant clinically significant bleeding symptoms occurred within 3 months prior to the first study medication 6. Uncontrollable third interstitial fluid accumulation within 2 weeks of initial study medication 7. History of clinically significant pulmonary diseases 8. Receive other anti-tumor treatments within 4 weeks before the first medication 9. Severe infection within 4 weeks before the first medication 10. Active, known or suspected autoimmune diseases, and a history of autoimmune diseases. 11. History of immunodeficiency 12. Individuals with active pulmonary tuberculosis infection within the year prior to enrollment 13. Chest radiation therapy patients who received\>30 Gy within 24 weeks prior to the first use of the investigational drug 14. The adverse reactions of previous anti-tumor treatments have not yet recovered to ≤ Grade I 15. Surgical treatment of important organs within 4 weeks prior to the first use of medication 16. Use attenuated live vaccine within 28 days prior to the first use of the investigational drug 17. There are other serious physical or mental illnesses or laboratory abnormalities present 18. Pregnant, lactating women, or female participants who plan to become pregnant within 14 months after the last use of the investigational drug during the study period 19. Having bleeding tendency, high risk of bleeding, coagulation dysfunction or thrombophilia tendency 20. Previously experienced hypertensive crisis or hypertensive encephalopathy 21. Suffering from significant vascular disease within 6 months prior to the first use of medication 22. Have undergone a biopsy or other minor surgery within 7 days prior to the first use of medication 23. Having severe, unhealed wounds, active ulcers, or untreated fractures 24. Gastrointestinal perforation occurred within 6 months prior to the first use of medication 25. 24-hour proteinuria quantification ≥ 1g within 7 days before the first medication 26. CT/MRI indicates tumor surrounding or invading large blood vessels

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Sun Yat-sen University Cancer Center

    RECRUITING

    Guangzhou, Guangdong, 510060, China

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