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Shock wave therapy fails to boost knee pain relief in small trial

NCT ID NCT07273110

Symptom relief Sponsor: Uğur Can Yalaki Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether adding shock wave therapy to a home exercise program could reduce knee pain and improve function in adults with patellofemoral pain syndrome (a common cause of front knee pain). Thirty-six people aged 18–45 were split into three groups: exercise only, shock waves only, or both. All groups improved over eight weeks, but the shock wave therapy did not provide extra benefit beyond exercise alone.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Radial Extracorporeal Shock Wave Therapy (ESWT) device
What this could lead to
If it works, this could offer a non-invasive option to ease knee pain and improve function for people with patellofemoral pain syndrome.
What could go wrong
This was a small, early trial with only 36 participants, and it found no added benefit of shock wave therapy over exercise alone. Results may not apply to everyone with knee pain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

36 people

The number who actually took part.

Started

Jan 2021

Finished

Sep 2021

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 to 45 years. * Clinical diagnosis of patellofemoral pain syndrome (PFPS) characterized by anterior or retropatellar knee pain lasting at least 8 weeks. * Pain provoked during at least two of the following activities: running, jumping, squatting, stair climbing, or prolonged sitting. * Worst knee pain score of ≥3 on the Visual Analog Scale (0-10). * Ability to understand and follow the exercise program and assessment procedures. * Provided written informed consent. Exclusion Criteria: * Evidence of intra-articular knee pathology other than grade 1-2 meniscal changes or grade 1 chondromalacia patella on MRI. * Clinical signs of patellar instability. * Localized tenderness indicating alternative diagnoses (e.g., patellar tendinopathy, iliotibial band syndrome, pes anserine bursitis). * History of knee surgery on the affected side. * Intra-articular injections (e.g., corticosteroids, hyaluronic acid, PRP) within the past 6 months. * Neurological or rheumatological disorders affecting the lower extremity. * Active infection, open wound, tumor, or severe dermatological condition at or near the ESWT application site. * Pregnancy.

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Conditions

The condition(s) this trial relates to.

patellofemoral pain syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Patellofemoral pain syndrome

Contacts and locations

Locations

  • Bursa Uludağ University Sports Medicine Clinic

    Bursa, Nilüfer, 16059, Turkey (Türkiye)

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