New magnesium spray could quiet chronic cough
NCT ID NCT07003347
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether a magnesium salt oral spray (SC0023) can reduce coughing in adults with chronic cough that doesn't respond to treatment or has no clear cause. About 20 participants used the spray or a placebo for 14 days, then switched. The main goal was to see if the spray lowered cough frequency over 24 hours.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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7 people
The number who actually took part.
- Started
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Dec 2024
- Finished
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Aug 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Males and females between 18-80 years * Capable of giving signed informed consent * Diagnosed with RCC (including unexplained chronic cough) for at least 6 months and at least 4 coughs per hour on average during awake hours at Screening. * Score ≥ 40 mm on cough severity VAS at screening. * Normal FEV/FVC * Women of child-bearing potential must use a highly effective contraception method during the study and for at least 14 days after the last dose. Exclusion Criteria: * Current smoker/vaper (all forms of smoking and inhaled substances, including, cannabis/tobacco smoke and nicotine vapors) or individuals who have given up smoking within the past 6 months, or those with \>20 pack-year smoking history. * Diagnosis of Chronic Obstructive Pulmonary Disease (COPD) bronchiectasis, idiopathic pulmonary fibrosis or uncontrolled asthma. * Respiratory tract infection within 4 weeks before screening. * History of malignancy in the last 5 years. * History of alcohol or drug abuse within the last 3 years. * Opioid use in last 7 days of screening. * History of a positive serologic test for, hepatitis B virus surface antigen, or hepatitis C virus. * Previous participation in clinical trial in last 30 days or 6-half lives of test drug activity. * Use of prohibited medications anti-tussive therapy, gabapentin, pregabalin, baclofen, tricyclics, systemic corticosteroids, ACE inhibitors, beta blockers. * Use of dietary supplements containing magnesium for the duration of the study. * History of myocardial infarction or other cardiac disorders. * History of any clinically significant or psychiatric condition that in the eyes of the Investigator or designee would not be suitable for this study. Or if in the eyes of the Investigator or designee may prove noncompliant to study procedures. * Spouses or other family members with a chronic cough in household or * Living and working in an excessively loud workplace (e.g. building site)
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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King Saud University Hospital
Riyadh, Saudi Arabia
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Other studies related to the condition(s) this trial covers.
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