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Could a persistent cough leave lasting scars on the lungs?

NCT ID NCT07659860

Knowledge-focused Sponsor: Medical University of Warsaw Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study investigates whether chronic cough lasting more than a year can injure and remodel the lower airways. Researchers will use chest CT scans and bronchoscopy to look for signs of airway damage and inflammation in adults with refractory chronic cough. The goal is to understand if the cough itself causes structural changes in the lungs.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If chronic cough is shown to cause airway damage, this could lead to earlier treatments to prevent long-term lung changes.
What could go wrong
This is a small observational study, so it may not prove cause and effect. Results may not apply to all people with chronic cough.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2022

Expected to finish

Aug 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

In 30 patients referred to the cough clinic for refractory chronic cough lasting more than 6 months

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria for the study group: 1. age between 18 and 75 years, 2. chronic cough of at least one year duration, with no previous treatment (at least 2 previous unsuccessful attempts at pharmacological treatment of cough) 3. negative history of smoking (at least 6 months of abstinence), 4. negative history of treatment with angiotensin-converting enzyme inhibitors (ACEI), 5. normal chest radiograph or with changes not relevant to cough formation, 6. no respiratory tract infections in the past 6 weeks, 7. written consent from the patient to participate in the study. Exclusion Criteria: 1. patients less than 18 and more than 75 years of age, 2. cough lasting less than 12 months, 3. active smoking or abstinence period of less than 6 months, 4. respiratory tract infection 6 weeks prior to inclusion or at the time of study conduct - retry inclusion after 6 weeks, 5. cancer or interstitial lung disease, 6. contraindications to functional testing, sputum induction or bronchoscopy

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Conditions

The condition(s) this trial relates to.

Chronic Cough

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic cough

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    4 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Department of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw

    RECRUITING

    Warsaw, Masovian Voivodeship, 02-097, Poland

  • Department of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw

    RECRUITING

    Warsaw, Warsaw, 02-097, Poland

  • Department of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw

    RECRUITING

    Warsaw, 02-097, Poland

  • Medical University of Warsaw

    RECRUITING

    Warsaw, 02-091, Poland

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