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Can weight training strengthen muscles in young CMT patients?

NCT ID NCT07152197

Symptom relief Sponsor: Universidad de La Frontera Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looks at whether an 8-week supervised resistance exercise program can improve muscle quality, physical function, and quality of life in young people aged 15–29 with Charcot-Marie-Tooth disease (a type of hereditary nerve disorder). Participants will do lower-body exercises three times a week, with weights gradually increasing. The researchers will compare results between those with the condition and healthy volunteers to see if the exercise helps more in those with greater baseline weakness.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Progressive resistance exercise training (supervised lower-limb exercises)
What this could lead to
If it works, this could show that resistance exercise is a safe, effective way to improve muscle function and quality of life in young people with Charcot-Marie-Tooth disease.
What could go wrong
This is a small, early-phase trial with only 22 participants, so results may not apply to everyone. The exercise program is short (8 weeks), and long-term benefits are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 22 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2025

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

15 to 29 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Men or women between 15 and 29 years of age with a diagnosis of hereditary sensorimotor polyneuropathy (HSPN) in any of its subtypes, living in the community (for experimental group). * Healthy men or women between 15 and 29 years of age living in the community (for control group). * Having active ankle movement within a range from plantarflexion to at least 0° of ankle dorsiflexion, allowing for strength training. Exclusion Criteria: * Osteoarticular or mobility impairments that prevent safe performance of resistance exercise training (e.g., ankle arthrodesis). * Use of nutritional supplements that may affect skeletal muscle regulation (leucine, glutamine, casein, whey protein, fatty acids, creatine, among others). * Untreated and/or uncontrolled chronic diseases or intellectual disability. * History of surgery * Participation in a resistance exercise training program within the past 6 months.

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Conditions

The condition(s) this trial relates to.

Charcot-Marie-Tooth disease polyneuropathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Charcot Marie Tooth disease (CMT) Polyneuropathy

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Temuco, Chile

    RECRUITING

    Temuco, La Araucanía, 4812790, Chile

  • Universidad de La Frontera

    ACTIVE_NOT_RECRUITING

    Temuco, La Araucanía, 4812790, Chile

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