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POTS puzzle: scientists probe blood pressure hormone link

NCT ID NCT00962949

Knowledge-focused Sponsor: Vanderbilt University Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This completed Phase 1 study at Vanderbilt University looked at how the renin-angiotensin-aldosterone system works in people with POTS, a condition that causes a rapid heart rate and dizziness upon standing. Researchers gave 28 participants (including healthy controls) a one-hour infusion of angiotensin II to measure changes in blood pressure and hormone levels. The goal was to better understand the disease process, not to test a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Angiotensin II
What this could lead to
If successful, this study could help explain why people with POTS have trouble regulating blood pressure and heart rate when standing.
What could go wrong
This is a small, early-phase study with only 28 participants, so results may not apply to everyone with POTS. It is designed to understand the disease, not to test a treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

28 people

The number who actually took part.

Start date

Apr 2009

Finished

Dec 2012

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 64 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis of postural tachycardia syndrome by the Vanderbilt Autonomic Dysfunction Center criteria * Age between 18-64 years * Male or females are eligible * Able and willing to provide informed consent * Healthy control subjects with no major medical problem (including postural tachycardia syndrome), free of medications during the study Exclusion Criteria: * Overt cause of postural tachycardia e.g., dehydration * Inability to give or withdraw informed consent * Pregnancy * Hypertension (BP \> 140/90) * Significant co-morbid condition * Other factors which in the investigator's opinion would prevent the subject from completing the protocol

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Conditions

The condition(s) this trial relates to.

Orthostatic Intolerance postural orthostatic tachycardia syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postural orthostatic tachycardia syndrome (POTS)

Contacts and locations

Locations

  • Vanderbilt University

    Nashville, Tennessee, 37232, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.