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Ear zap might tame racing heart in POTS

NCT ID NCT07026643

Symptom relief Sponsor: University of Calgary Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study tests a non-invasive ear stimulation device (aVNT) in 30 people with Postural Orthostatic Tachycardia Syndrome (POTS). The goal is to see if it can reduce rapid heart rate upon standing, improve blood flow to the brain, and ease other symptoms like brain fog and fatigue. Participants will be randomly assigned to receive either active stimulation or a sham (placebo) device for 3 months.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Dec 2031

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * POTS Patients: POTS patients will meet Canadian Cardiovascular Society criteria. 6 POTS patients will have orthostatic tachycardia \>30 bpm increase in HR within 10 minutes of upright posture \[\>40 bpm in patients \<20 years\]), in the absence of orthostatic hypotension (drop in BP \>20/10 mmHg), chronic symptoms of orthostatic intolerance, and no obvious cause for the tachycardia. * Age between 18-80 years * Male and female subjects are eligible * Able and willing to provide informed consent Exclusion Criteria: * Unable to give informed consent * Stimulant use within one week of the study * Systolic blood pressure \>150 mm Hg and/or diastolic blood pressure \> 100 mm Hg * Neurogenic orthostatic hypotension, prior stroke, myocardial infarction or heart failure, hematocrit \< 28% * Significant comorbidities (cardiovascular, metabolic, renal, respiratory, cancer, immunological or hematological) * History of vagotomy, permanent pacemakers * Pregnant or nursing females.

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Conditions

The condition(s) this trial relates to.

postural orthostatic tachycardia syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postural orthostatic tachycardia syndrome (POTS)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

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