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Which drug keeps the nose Blood-Free during surgery? a Head-to-Head trial

NCT ID NCT07660562

Disease control Sponsor: Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial compares two medications—remifentanil and nicardipine—given during nasal surgery to lower blood pressure and reduce bleeding. Both are already used in practice, but it is unclear which provides a better surgical view and fewer side effects. The study includes adults undergoing elective nasal surgery and measures surgical field quality, blood loss, and recovery time.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
remifentanil and nicardipine
What this could lead to
If one drug works better, it could become the preferred method for controlling bleeding during nasal surgeries, leading to safer procedures and better outcomes.
What could go wrong
This is a small, early-stage trial with only 44 participants, so results may not apply to all patients. Both drugs have known side effects like low blood pressure or slow heart rate.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 44 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2026

An estimate. Start dates often move.

Expected to finish

Jul 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age \> 18 years * ASA physical status I-II * Scheduled for elective nasal surgery * No known serious cardiovascular, respiratory, renal, or hepatic disease * No known allergy to remifentanil or nicardipine * No chronic use of beta-blockers, calcium channel blockers, or antihypertensive agents * Not pregnant or breastfeeding * BMI ≤ 35 kg/m² * No emergency surgical indication * Written informed consent obtained Exclusion Criteria: * Age \< 18 years * ASA III or above * Known serious cardiovascular, respiratory, renal, or hepatic disease * Known allergy to remifentanil or nicardipine * Chronic use of beta-blockers, calcium channel blockers, or antihypertensive agents * Pregnancy or breastfeeding * Morbid obesity (BMI \> 35 kg/m²) * Emergency surgery * Refusal to participate

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anesthesia Controlled hypotension for nasal surgeries Nasal surgery

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

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