Could a blood pressure pill shield brain cancer patients from memory loss?

NCT ID NCT03475186

Prevention Sponsor: Wake Forest University Health Sciences Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study tested whether ramipril, a drug typically used for high blood pressure, can help prevent memory loss in people with glioblastoma who are receiving brain radiation. 75 patients took ramipril daily during and after chemoradiation. Researchers measured memory and thinking skills using standard tests over several months. The goal was to see if this approach could reduce the cognitive side effects of brain radiotherapy.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: Ramipril (a blood pressure medication)
What this could lead to: If it works, this could point toward a way to protect memory in brain cancer patients receiving radiation therapy.
What could go wrong: This is a small, early-phase pilot study with no control group, so results are preliminary. The drug may not show a clear benefit, and side effects from ramipril are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

75 people

The number who actually took part.

Started

Mar 2019

Finished

Mar 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Histologically proven diagnosis of glioblastoma or gliosarcoma (World Health Organization \[WHO\] grade IV) obtained at the time of a partial or gross total resection of the tumor. Patients who undergo a stereotactic needle biopsy alone are not eligible. * The tumor must have a supratentorial component. * History/physical examination within 14 days prior to enrollment. * The patient must have recovered from the effects of surgery, postoperative infection, and other complications before enrollment * Patient planning to receive brain RT, and concurrent and adjuvant temozolomide chemotherapy for six weeks as per standard of care therapy. Use of the Optune® (also known as Tumor Treating Fields or TTFields) device is allowed at provider discretion, but must begin after the Month 1 Post RT (10 week \[wk\]) Neurocognitive-PRO assessment. * Study drug (Ramipril) must be given \>= 21 days and ≤ 42 days after surgery. * All available brain magnetic resonance imaging (MRI) or computed tomography (CT) imaging reports from surgery to study completion must be submitted. This includes any post-operative or pre-radiation scan reports. * Eastern Cooperative Oncology Group (ECOG) 0, 1 or 2 * Absolute neutrophil count (ANC) \>= 1,500 cells/mm\^3 (obtained within 14 days prior to enrollment) * Platelets \>= 100,000 cells/mm\^3 (obtained within 14 days prior to enrollment) * Hemoglobin \>= 10.0 g/dl (Note: The use of transfusion or other intervention to achieve hemoglobin \[Hgb\] \>= 10.0 g/dl is acceptable) (obtained within 14 days prior to enrollment) * Blood urea nitrogen (BUN) =\< 30 mg/dl within 14 days prior to enrollment * Creatinine =\< 1.7 mg/dl within 14 days prior to enrollment * Total bilirubin =\< 2.0 mg/dl within 14 days prior to enrollment * Alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =\< 3 x normal range within 14 days prior to enrollment * Patient must provide study specific informed consent prior to study entry * Baseline potassium level \<5.0 mEq/L. High potassium values that are thought to be a result of sample hemolysis may be repeated to determine an accurate potassium level and to determine potential study eligibility. Likewise high potassium values thought to be a result of potassium supplementation may be repeated at an appropriate time (5 half-lives after supplement discontinuation) to determine potential study eligibility. Patient must be able to complete neurocognitive tests in the English language * Women of childbearing potential and male participants must practice adequate contraception * For females of child-bearing potential, negative serum or urine pregnancy test within 14 days of enrollment * Local site must be follow the standard GBM radiation treatment dosimetry plan * For patients who will be treated with the Optune® device in addition to standard of care radiation plus concurrent and adjuvant temozolomide, the following inclusion criteria also apply: * Patients must have only a supratentorial glioblastoma * The treating physician must be a qualified provider having successfully completed the training course provided by Novocure, the device manufacturer * Patients with prior malignancies if all treatment for that malignancy was completed at least 2 years before registration and the patient has no evidence of disease. Exclusion Criteria: * Prior allergic reaction or intolerance to angiotensin-converting-enzyme (ACE) inhibitor * Hypotension (\< 110 mg Hg systolic) at the time of enrollment * Renal insufficiency with creatinine clearance of \< 40 ml/min (at time of enrollment) * Solitary kidney or known renal artery stenosis * Current ACE inhibitor or angiotensin receptor blocker use. Patients can come off ACE inhibitors or angiotensin receptor blockers for 1 week to be eligible for this study. * Prior invasive malignancy (except for non-melanomatous skin cancer) unless disease free for ≥ 2 years. (For example, carcinoma in situ of the breast, oral cavity, and cervix are all permissible). * Recurrent or multifocal malignant gliomas * Metastases detected below the tentorium or beyond the cranial vault * Prior chemotherapy or radiosensitizers for cancers of the head and neck region; note that prior chemotherapy for a different cancer is allowable, except prior temozolomide. Prior use of Gliadel wafers or any other intratumoral or intracavitary treatment are not permitted. * Prior radiotherapy to the head or neck (except for T1 glottic cancer), resulting in overlap of radiation fields. * Severe active co-morbidity, defined as follows: * Acute bacterial or fungal infection requiring intravenous antibiotics at the time of enrollment * Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy at the time of enrollment. * Known HIV positivity or acquired immune deficiency syndrome (AIDS) based upon current CDC definition; note, however, that HIV testing is not required for entry into this protocol. The need to exclude patients with AIDS from this protocol is necessary because the treatments involved in this protocol may be significantly immunosuppressive. * Active connective tissue disorders, such as lupus or scleroderma, that in the opinion of the treating physician may put the patient at high risk for radiation toxicity. * Any other major medical illnesses or psychiatric impairments that in the investigator's opinion will prevent administration or completion of protocol therapy. * Pregnancy or women of childbearing potential and men who are sexually active and not willing/able to use medically acceptable forms of contraception; this exclusion is necessary because the treatment involved in this study may be significantly teratogenic. * Patients treated on any other therapeutic clinical protocols within 30 days prior to study entry or during participation in the study unless they involve standard of care or over the counter therapies or do not involve a drug therapy. * Patients planning to receive therapeutic antitumor agents (excluding use of the Tumor Treating Fields (TTFields or Optune®) device after the Month 1 Post RT (10 wk) Neurocognitive-PRO assessment.) in addition to standard radiation and concurrent and adjuvant temozolomide are not eligible to participate in this study. * Patients with impaired decision-making capacity; this exclusion is necessary because such patients may not be able to adequately give informed consent. * Pregnant or lactating women, due to possible adverse effect on the developing fetus or infant due to study drug. * For patients who will be treated with the Optune® device in addition to standard of care radiation plus concurrent and adjuvant temozolomide, the following exclusion criteria also apply: * Optune® is not permitted in patients who have an active implanted medical device, skull defect (such as, missing bone with no replacement) or bullet fragments. Examples of active electronic devices include deep brain stimulators, spinal cord stimulators, vagus nerve stimulators, pacemakers, defibrillators, and programmatic shunts. * Optune® is not permitted in patients who are known to be sensitive to conductive hydrogels. Examples of conductive hydrogels are gels used on electrocardiogram (ECG) stickers or transcutaneous electrical nerve stimulation (TENS) electrodes. * Patients being treated with Memantine, Donepezil, and/or medications prescribed to enhance cognition.

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Conditions

The condition(s) this trial relates to.

brain cancer Cognitive Dysfunction glioblastoma gliosarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chemoradiation Cognitive decline Glioblastoma Radiotherapy; complications

Contacts and locations

Locations

21st Century Oncology-Pontiac

Pontiac, Michigan, 48341, United States
Abbott-Northwestern Hospital

Minneapolis, Minnesota, 55407, United States
Academic Hematology Oncology Specialists

Grosse Pointe Woods, Michigan, 48236, United States
Adena Regional Medical Center

Chillicothe, Ohio, 45601, United States
Advanced Breast Care Center PLLC

Warren, Michigan, 48088, United States
Alaska Breast Care and Surgery LLC

Anchorage, Alaska, 99508, United States
Alaska Oncology and Hematology LLC

Anchorage, Alaska, 99508, United States
Alaska Women's Cancer Care

Anchorage, Alaska, 99508, United States
Alegent Health Bergan Mercy Medical Center

Omaha, Nebraska, 68124, United States
Alegent Health Immanuel Medical Center

Omaha, Nebraska, 68122, United States
Alegent Health Lakeside Hospital

Omaha, Nebraska, 68130, United States
Alegent Health Mercy Hospital

Council Bluffs, Iowa, 51503, United States
Anchorage Associates in Radiation Medicine

Anchorage, Alaska, 98508, United States
Anchorage Oncology Centre

Anchorage, Alaska, 99508, United States
Anchorage Radiation Therapy Center

Anchorage, Alaska, 99504, United States
Annie Penn Memorial Hospital

Reidsville, North Carolina, 27320, United States
Ascension Borgess Cancer Center

Oshtemo, Michigan, 49008, United States
Ascension Saint John Hospital

Detroit, Michigan, 48236, United States
Ascension Saint Joseph Hospital

Tawas City, Michigan, 48764, United States
Ascension Saint Mary's Hospital

Saginaw, Michigan, 48601, United States
Ascension Via Christi Hospitals Wichita

Wichita, Kansas, 67214, United States
Aspirus Cancer Care - Wisconsin Rapids

Sacramento, California, 95823, United States
Aspirus Cancer Care - Wisconsin Rapids

Wisconsin Rapids, Wisconsin, 54494, United States
Aspirus Langlade Hospital

Irvine, California, 92618, United States
Aspirus Langlade Hospital

Antigo, Wisconsin, 54409, United States
Aspirus Medford Hospital

Medford, Wisconsin, 54451, United States
Aspirus Regional Cancer Center

Sacramento, California, 95816, United States
Aspirus Regional Cancer Center

Wausau, Wisconsin, 54401, United States
AtlantiCare Health Park-Cape May Court House

Cape May Court House, New Jersey, 08210, United States
AtlantiCare Surgery Center

Egg Harbor, New Jersey, 08234, United States
Aurora Saint Luke's Medical Center

Milwaukee, Wisconsin, 53215, United States
Bay Area Hospital

Coos Bay, Oregon, 97420, United States
Beebe Medical Center

Lewes, Delaware, 19958, United States
Bethesda North Hospital

Cincinnati, Ohio, 45242, United States
Bhadresh Nayak MD PC-Sterling Heights

Sterling Heights, Michigan, 48312, United States
Borgess Medical Center

Kalamazoo, Michigan, 49048, United States
Broadlawns Medical Center

Des Moines, Iowa, 50314, United States
Bronson Battle Creek

Battle Creek, Michigan, 49017, United States
Bronson Methodist Hospital

Kalamazoo, Michigan, 49007, United States
CHI Health Good Samaritan

Kearney, Nebraska, 68847, United States
CHI Saint Vincent Cancer Center Hot Springs

Hot Springs, Arkansas, 71913, United States
Cambridge Medical Center

Cambridge, Minnesota, 55008, United States
Cancer Care Center of O'Fallon

O'Fallon, Illinois, 62269, United States
Cancer Care Specialists of Illinois - Decatur

Decatur, Illinois, 62526, United States
Cancer Center at Saint Joseph's

Phoenix, Arizona, 85004, United States
Cancer Center of Kansas - Wichita

Wichita, Kansas, 67214, United States
Cancer Center of Kansas-Wichita Medical Arts Tower

Wichita, Kansas, 67208, United States
Cancer Center of Western Wisconsin

New Richmond, Wisconsin, 54017, United States
Cancer and Hematology Centers of Western Michigan - Norton Shores

Norton Shores, Michigan, 49444, United States
Capital Region Southwest Campus

Jefferson City, Missouri, 65109, United States
Carle Cancer Center

Urbana, Illinois, 61801, United States
Carle Cancer Center NCI Community Oncology Research Program

Urbana, Illinois, 61801, United States
Carle Cancer Institute Normal

Atlanta, Georgia, 30310, United States
Carle Physician Group-Effingham

Effingham, Illinois, 62401, United States
Carle Physician Group-Mattoon/Charleston

Mattoon, Illinois, 61938, United States
Carle on Vermilion

Danville, Illinois, 61832, United States
Caro Cancer Center

Caro, Michigan, 48723, United States
Castle Medical Center

Kailua, Hawaii, 96734, United States
Central Care Cancer Center - Bolivar

Bolivar, Missouri, 65613, United States
Central Care Cancer Center - Garden City

Garden City, Kansas, 67846, United States
Central Care Cancer Center - Great Bend

Great Bend, Kansas, 67530, United States
Central Carolina Surgery

Greensboro, North Carolina, 27401, United States
Central Ohio Breast and Endocrine Surgery

Gahanna, Ohio, 43230, United States
Centralia Oncology Clinic

Centralia, Illinois, 62801, United States
Christiana Care Health System-Christiana Hospital

Newark, Delaware, 19718, United States
Christiana Care Health System-Concord Health Center

Chadds Ford, Pennsylvania, 19317, United States
Clackamas Radiation Oncology Center

Clackamas, Oregon, 97015, United States
Columbus NCI Community Oncology Research Program

Columbus, Colorado, 43215, United States
Columbus Oncology and Hematology Associates

Dublin, Ohio, 43016, United States
Columbus Oncology and Hematology Associates Inc

Columbus, Ohio, 43214, United States
Commonwealth Cancer Center-Corbin

Corbin, Kentucky, 40701, United States
Cone Health Cancer Center

Greensboro, North Carolina, 27403, United States
Cone Health Cancer Center at Alamance Regional

Burlington, North Carolina, 27215, United States
Cone Health Cancer Center at Asheboro

Asheboro, North Carolina, 27203, United States
Cone Heath Cancer Center at Mebane

Mebane, North Carolina, 27302, United States
Cox Cancer Center Branson

Branson, Missouri, 65616, United States
CoxHealth South Hospital

Springfield, Missouri, 65807, United States
Creighton University Medical Center

Omaha, Nebraska, 68131, United States
Crossroads Cancer Center

Effingham, Illinois, 62401, United States
Culicchia Neurological Clinic LLC

Marrero, Louisiana, 70072, United States
Decatur Memorial Hospital

Decatur, Illinois, 62526, United States
Delaware Clinical and Laboratory Physicians PA

Newark, Delaware, 19713, United States
Delaware Health Center-Grady Cancer Center

Delaware, Ohio, 43015, United States
Delbert Day Cancer Institute at PCRMC

Rolla, Missouri, 65401, United States
Diagnostic and Treatment Center

Weston, Wisconsin, 54476, United States
Doctors Hospital

Columbus, Ohio, 43228, United States
Dublin Methodist Hospital

Dublin, Ohio, 43016, United States
Duluth Clinic Ashland

Ashland, Wisconsin, 54806, United States
Essentia Health - Deer River Clinic

Deer River, Minnesota, 56636, United States
Essentia Health - Fosston

Fosston, Minnesota, 56542, United States
Essentia Health - Jamestown Clinic

Jamestown, North Dakota, 58401, United States
Essentia Health - Park Rapids

Park Rapids, Minnesota, 56470, United States
Essentia Health Cancer Center

Duluth, Minnesota, 55805, United States
Essentia Health Cancer Center-South University Clinic

Fargo, North Dakota, 58103, United States
Essentia Health Hibbing Clinic

Hibbing, Minnesota, 55746, United States
Essentia Health Saint Joseph's Medical Center

Brainerd, Minnesota, 56401, United States
Essentia Health Saint Mary's - Detroit Lakes Clinic

Detroit Lakes, Minnesota, 56501, United States
Essentia Health Saint Mary's Medical Center

Duluth, Minnesota, 55805, United States
Essentia Health Sandstone

Sandstone, Minnesota, 55072, United States
Essentia Health Virginia Clinic

Virginia, Minnesota, 55792, United States
FHP Health Center-Guam

Tamuning, 96913, Guam
Fairfield Medical Center

Lancaster, Ohio, 43130, United States
Fairview Clinics and Surgery Center Maple Grove

Maple Grove, Minnesota, 55369, United States
Fairview Lakes Medical Center

Wyoming, Minnesota, 55092, United States
Fairview Northland Medical Center

Princeton, Minnesota, 55371, United States
Fairview Ridges Hospital

Burnsville, Minnesota, 55337, United States
Fairview Southdale Hospital

Edina, Minnesota, 55435, United States
Flaget Memorial Hospital

Bardstown, Kentucky, 40004, United States
Freeman Health System

Joplin, Missouri, 64804, United States
Geisinger Medical Center

Danville, Pennsylvania, 17822, United States
Geisinger Medical Oncology-Lewisburg

Lewisburg, Pennsylvania, 17837, United States
Geisinger Wyoming Valley/Henry Cancer Center

Wilkes-Barre, Pennsylvania, 18711, United States
Genesee Cancer and Blood Disease Treatment Center

Flint, Michigan, 48503, United States
Genesee Hematology Oncology PC

Flint, Michigan, 48503, United States
Genesis Healthcare System Cancer Care Center

Zanesville, Ohio, 43701, United States
Genesys Hurley Cancer Institute

Flint, Michigan, 48503, United States
Good Samaritan Hospital - Cincinnati

Cincinnati, Ohio, 45220, United States
Good Samaritan Regional Health Center

Mount Vernon, Illinois, 62864, United States
Grady Memorial Hospital

Delaware, Ohio, 43015, United States
Grant Medical Center

Columbus, Ohio, 43215, United States
Great Lakes Cancer Management Specialists-Doctors Park

East China Township, Michigan, 48054, United States
Great Lakes Cancer Management Specialists-Macomb Medical Campus

Macomb, Michigan, 48044, United States
Great Lakes Cancer Management Specialists-Macomb Professional Building

Warren, Michigan, 48093, United States
Great Lakes Cancer Management Specialists-Van Elslander Cancer Center

Grosse Pointe Woods, Michigan, 48236, United States
Greater Regional Medical Center

Creston, Iowa, 50801, United States
Gundersen Lutheran Medical Center

La Crosse, Wisconsin, 54601, United States
Hawaii Cancer Care - Savio

‘Aiea, Hawaii, 96701, United States
Hawaii Cancer Care - Westridge

‘Aiea, Hawaii, 96701, United States
Hawaii Cancer Care Inc - Waterfront Plaza

Honolulu, Hawaii, 96813, United States
Hawaii Diagnostic Radiology Services LLC

Honolulu, Hawaii, 96817, United States
Health Partners Inc

Minneapolis, Minnesota, 55454, United States
Heartland Cancer Research NCORP

Decatur, Illinois, 62526, United States
Heartland Regional Medical Center

Saint Joseph, Missouri, 64506, United States
Helen DeVos Children's Hospital at Spectrum Health

Grand Rapids, Michigan, 49503, United States
Helen F Graham Cancer Center

Newark, Delaware, 19713, United States
Hematology Oncology Consultants-Clarkston

Clarkston, Michigan, 48346, United States
Hennepin County Medical Center

Minneapolis, Minnesota, 55415, United States
Highline Medical Center-Main Campus

Burien, Washington, 98166, United States
Holy Cross Hospital

Fort Lauderdale, Florida, 33308, United States
Hope Cancer Center

Pontiac, Michigan, 48341, United States
Hurley Medical Center

Flint, Michigan, 48503, United States
Huron Gastroenterology PC

Ypsilanti, Michigan, 48106, United States
IHA Hematology Oncology Consultants-Ann Arbor

Ypsilanti, Michigan, 48197, United States
IHA Hematology Oncology Consultants-Brighton

Brighton, Michigan, 48114, United States
IHA Hematology Oncology Consultants-Canton

Canton, Michigan, 48188, United States
IHA Hematology Oncology Consultants-Chelsea

Chelsea, Michigan, 48118, United States
Illinois CancerCare - Washington

Washington, Illinois, 61571, United States
Illinois CancerCare-Bloomington

Bloomington, Illinois, 61704, United States
Illinois CancerCare-Canton

Canton, Illinois, 61520, United States
Illinois CancerCare-Carthage

Carthage, Illinois, 62321, United States
Illinois CancerCare-Dixon

Dixon, Illinois, 61021, United States
Illinois CancerCare-Eureka

Eureka, Illinois, 61530, United States
Illinois CancerCare-Galesburg

Galesburg, Illinois, 61401, United States
Illinois CancerCare-Kewanee Clinic

Kewanee, Illinois, 61443, United States
Illinois CancerCare-Macomb

Macomb, Illinois, 61455, United States
Illinois CancerCare-Ottawa Clinic

Ottawa, Illinois, 61350, United States
Illinois CancerCare-Pekin

Pekin, Illinois, 61554, United States
Illinois CancerCare-Peoria

Peoria, Illinois, 61615, United States
Illinois CancerCare-Peru

Peru, Illinois, 61354, United States
Illinois CancerCare-Princeton

Princeton, Illinois, 61356, United States
Iowa Lutheran Hospital

Des Moines, Iowa, 50316, United States
Iowa Methodist Medical Center

Des Moines, Iowa, 50309, United States
Iowa-Wide Oncology Research Coalition NCORP

Des Moines, Iowa, 50309, United States
Island Urology

Honolulu, Hawaii, 96813, United States
Island Urology-Hilo

Hilo, Hawaii, 96720, United States
Jewish Hospital

Louisville, Kentucky, 40202, United States
Jewish Hospital Medical Center South

Shepherdsville, Kentucky, 40165, United States
John H Stroger Jr Hospital of Cook County

Chicago, Illinois, 60612, United States
Kadlec Clinic Hematology and Oncology

Kennewick, Washington, 99336, United States
Kaiser Permanente Los Angeles Medical Center

Los Angeles, California, 90027, United States
Kapiolani Medical Center for Women and Children

Honolulu, Hawaii, 96826, United States
Katmai Oncology Group

Anchorage, Alaska, 99508, United States
Knox Community Hospital

Mount Vernon, Ohio, 43050, United States
Kuakini Medical Center

Honolulu, Hawaii, 96817, United States
LSU Health Sciences Center at Shreveport

Shreveport, Louisiana, 71103, United States
Lake Region Healthcare Corporation-Cancer Care

Fergus Falls, Minnesota, 56537, United States
Lakeland Hospital Niles

Niles, Michigan, 49120, United States
Lakeland Medical Center Saint Joseph

Saint Joseph, Michigan, 49085, United States
Lakeview Hospital

Stillwater, Minnesota, 55082, United States
Lankenau Medical Center

Wynnewood, Pennsylvania, 19096, United States
Lawrence Memorial Hospital

Lawrence, Kansas, 66044, United States
Lehigh Valley Hospital - Muhlenberg

Bethlehem, Pennsylvania, 18017, United States
Lehigh Valley Hospital-Cedar Crest

Allentown, Pennsylvania, 18103, United States
Lehigh Valley Hospital-Hazelton

Hazleton, Pennsylvania, 18201, United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

Savannah, Georgia, 31405, United States
Licking Memorial Hospital

Newark, Ohio, 43055, United States
Littleton Adventist Hospital

Littleton, Colorado, 80122, United States
Longmont United Hospital

Longmont, Colorado, 80501, United States
Louisiana State University Health Science Center

New Orleans, Louisiana, 70112, United States
Lovelace Medical Center-Downtown

Albuquerque, New Mexico, 87102, United States
Lovelace Medical Center-Saint Joseph Square

Albuquerque, New Mexico, 87102, United States
Lovelace Radiation Oncology

Albuquerque, New Mexico, 87109, United States
Macomb Hematology Oncology PC

Warren, Michigan, 48093, United States
Margaret R Pardee Memorial Hospital

Hendersonville, North Carolina, 28791, United States
Marie Yeager Cancer Center

Saint Joseph, Michigan, 49085, United States
Marietta Memorial Hospital

Marietta, Ohio, 45750, United States
Marshfield Clinic - Ladysmith Center

Ladysmith, Wisconsin, 54848, United States
Marshfield Clinic - Wisconsin Rapids Center

Wisconsin Rapids, Wisconsin, 54494, United States
Marshfield Clinic Stevens Point Center

Stevens Point, Wisconsin, 54482, United States
Marshfield Clinic-Chippewa Center

Chippewa Falls, Wisconsin, 54729, United States
Marshfield Clinic-Minocqua Center

Minocqua, Wisconsin, 54548, United States
Marshfield Clinic-Wausau Center

Wausau, Wisconsin, 54401, United States
Marshfield Medical Center - Weston

Weston, Wisconsin, 54476, United States
Marshfield Medical Center-EC Cancer Center

Eau Claire, Wisconsin, 54701, United States
Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, 54449, United States
Marshfield Medical Center-Rice Lake

Rice Lake, Wisconsin, 54868, United States
Medical Oncology and Hematology Associates-Des Moines

Des Moines, Iowa, 50309, United States
Medical Oncology and Hematology Associates-Laurel

Des Moines, Iowa, 50314, United States
Medical Oncology and Hematology Associates-West Des Moines

Clive, Iowa, 50325, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Memorial Hospital of Carbondale

Carbondale, Illinois, 62902, United States
Memorial Medical Center

Springfield, Illinois, 62781, United States
Mercy Cancer Center-West Lakes

Clive, Iowa, 50325, United States
Mercy Clinic-Rolla-Cancer and Hematology

Rolla, Missouri, 65401, United States
Mercy Health - Perrysburg Hospital

Perrysburg, Ohio, 43551, United States
Mercy Health - Saint Anne Hospital

Toledo, Ohio, 43623, United States
Mercy Health - Saint Vincent Hospital

Toledo, Ohio, 43608, United States
Mercy Health Mercy Campus

Muskegon, Michigan, 49444, United States
Mercy Health Saint Mary's

Grand Rapids, Michigan, 49503, United States
Mercy Health Sylvania Radiation Oncology Center

Toledo, Ohio, 43623, United States
Mercy Hospital

Coon Rapids, Minnesota, 55433, United States
Mercy Hospital Fort Smith

Fort Smith, Arkansas, 72903, United States
Mercy Hospital Joplin

Joplin, Missouri, 64804, United States
Mercy Hospital Oklahoma City

Oklahoma City, Oklahoma, 73120, United States
Mercy Hospital Saint Louis

St Louis, Missouri, 63141, United States
Mercy Hospital South

St Louis, Missouri, 63128, United States
Mercy Hospital Springfield

Springfield, Missouri, 65804, United States
Mercy Hospital Washington

Washington, Missouri, 63090, United States
Mercy Medical Center

Durango, Colorado, 81301, United States
Mercy Medical Center - Des Moines

Des Moines, Iowa, 50314, United States
Mercy Medical Center-West Lakes

West Des Moines, Iowa, 50266, United States
Methodist Medical Center of Illinois

Peoria, Illinois, 61636, United States
Methodist West Hospital

West Des Moines, Iowa, 50266-7700, United States
Metro Health Hospital

Wyoming, Michigan, 49519, United States
Michigan Breast Specialists-Grosse Pointe Woods

Grosse Pointe Woods, Michigan, 48236, United States
Michigan Breast Specialists-Macomb Township

Macomb, Michigan, 48044, United States
Michigan Breast Specialists-Warren

Warren, Michigan, 48093, United States
Michigan Cancer Research Consortium NCORP

Ann Arbor, Michigan, 48106, United States
Midlands Community Hospital

Papillion, Nebraska, 68046, United States
Miller-Dwan Hospital

Duluth, Minnesota, 55805, United States
Minnesota Oncology - Burnsville

Burnsville, Minnesota, 55337, United States
Minnesota Oncology Hematology PA-Maplewood

Maplewood, Minnesota, 55109, United States
Minnesota Oncology Hematology PA-Woodbury

Woodbury, Minnesota, 55125, United States
Mission Hope Medical Oncology - Arroyo Grande

Arroyo Grande, California, 93420, United States
Mission Hope Medical Oncology - Santa Maria

Santa Maria, California, 93444, United States
Mission Hospital

Asheville, North Carolina, 28801, United States
Missouri Baptist Medical Center

St Louis, Missouri, 63131, United States
Missouri Baptist Outpatient Center-Sunset Hills

Sunset Hills, Missouri, 63127, United States
Missouri Baptist Sullivan Hospital

Sullivan, Missouri, 63080, United States
Monticello Cancer Center

Monticello, Minnesota, 55362, United States
Mount Carmel East Hospital

Columbus, Ohio, 43213, United States
Mount Carmel Grove City Hospital

Grove City, Ohio, 43123, United States
Mount Carmel Health Center West

Columbus, Ohio, 43222, United States
Munson Medical Center

Traverse City, Michigan, 49684, United States
Nebraska Cancer Specialists/Oncology Hematology West PC

Grand Island, Nebraska, 68803, United States
New Ulm Medical Center

New Ulm, Minnesota, 56073, United States
Newark Radiation Oncology

Newark, Ohio, 43055, United States
Newland Medical Associates-Clarkston

Clarkston, Michigan, 48346, United States
Newland Medical Associates-Pontiac

Pontiac, Michigan, 48341, United States
North Memorial Medical Health Center

Robbinsdale, Minnesota, 55422, United States
Northside Hospital

Atlanta, Georgia, 30342, United States
Northside Hospital - Duluth

Duluth, Georgia, 30096, United States
Northside Hospital - Gwinnett

Lawrenceville, Georgia, 30046, United States
Northwell Health Imbert Cancer Center

Bay Shore, New York, 11706, United States
Northwell Health/Center for Advanced Medicine

Lake Success, New York, 11042, United States
Northwest Wisconsin Cancer Center

Ashland, Wisconsin, 54806, United States
Novant Health Breast Surgery - Greensboro

Greensboro, North Carolina, 27403, United States
Novant Health Cancer Institute - Kernersville

Kernersville, North Carolina, 27284, United States
Novant Health Cancer Institute - Mount Airy

Mount Airy, North Carolina, 27030, United States
Novant Health Cancer Institute - Statesville

Statesville, North Carolina, 28625, United States
Novant Health Cancer Institute - Thomasville

Thomasville, North Carolina, 27360, United States
Novant Health Cancer Institute - Wilkesboro

Wilkesboro, North Carolina, 28659, United States
Novant Health Forsyth Medical Center

Winston-Salem, North Carolina, 27103, United States
OSF Saint Anthony's Health Center

Alton, Illinois, 62002, United States
OhioHealth Mansfield Hospital

Mansfield, Ohio, 44903, United States
OhioHealth Marion General Hospital

Marion, Ohio, 43302, United States
Oncology Hematology Associates of Saginaw Valley PC

Saginaw, Michigan, 48604, United States
Pacific Central Coast Health Center-San Luis Obispo

San Luis Obispo, California, 93401, United States
Pali Momi Medical Center

‘Aiea, Hawaii, 96701, United States
Paoli Memorial Hospital

Paoli, Pennsylvania, 19301, United States
Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, Minnesota, 55416, United States
Parker Adventist Hospital

Parker, Colorado, 80138, United States
Parkland Health Center - Farmington

Farmington, Missouri, 63640, United States
PeaceHealth Saint John Medical Center

Longview, Washington, 98632, United States
PeaceHealth Saint Joseph Medical Center

Bellingham, Washington, 98225, United States
PeaceHealth Southwest Medical Center

Vancouver, Washington, 98664, United States
PeaceHealth United General Medical Center

Sedro-Woolley, Washington, 98284, United States
Penrose-Saint Francis Healthcare

Colorado Springs, Colorado, 80907, United States
Pocono Medical Center

East Stroudsburg, Pennsylvania, 18301, United States
Porter Adventist Hospital

Denver, Colorado, 80210, United States
Prisma Health Cancer Institute - Butternut

Greenville, South Carolina, 29605, United States
Prisma Health Cancer Institute - Easley

Easley, South Carolina, 29640, United States
Prisma Health Cancer Institute - Eastside

Greenville, South Carolina, 29615, United States
Prisma Health Cancer Institute - Faris

Greenville, South Carolina, 29605, United States
Prisma Health Cancer Institute - Greer

Greer, South Carolina, 29650, United States
Prisma Health Cancer Institute - Seneca

Seneca, South Carolina, 29672, United States
Prisma Health Cancer Institute - Spartanburg

Boiling Springs, South Carolina, 29316, United States
Prisma Health Greenville Memorial Hospital

Greenville, South Carolina, 29605, United States
Providence Alaska Medical Center

Anchorage, Alaska, 99508, United States
Providence Cancer Institute Clackamas Clinic

Clackamas, Oregon, 97015, United States
Providence Newberg Medical Center

Newberg, Oregon, 97132, United States
Providence Portland Medical Center

Portland, Oregon, 97213, United States
Providence Regional Cancer Partnership

Everett, Washington, 98201, United States
Providence Regional Cancer System-Aberdeen

Aberdeen, Washington, 98520, United States
Providence Regional Cancer System-Centralia

Centralia, Washington, 98531, United States
Providence Regional Cancer System-Shelton

Shelton, Washington, 98584, United States
Providence Regional Cancer System-Yelm

Yelm, Washington, 98597, United States
Providence Saint Joseph Medical Center/Disney Family Cancer Center

Burbank, California, 91505, United States
Providence Saint Mary Regional Cancer Center

Walla Walla, Washington, 99362, United States
Providence Saint Vincent Medical Center

Portland, Oregon, 97225, United States
Queen's Cancer Cenrer - POB I

Honolulu, Hawaii, 96813, United States
Queen's Cancer Center - Kuakini

Honolulu, Hawaii, 96817, United States
Queen's Cancer Center - Pearlridge

‘Aiea, Hawaii, 96701, United States
Queen's Medical Center

Honolulu, Hawaii, 96813, United States
Randolph Hospital

Asheboro, North Carolina, 27203, United States
Regional Cancer Center-Lee Memorial Health System

Fort Myers, Florida, 33905, United States
Regions Hospital

Saint Paul, Minnesota, 55101, United States
Rice Memorial Hospital

Willmar, Minnesota, 56201, United States
Ridgeview Medical Center

Waconia, Minnesota, 55387, United States
Riverside Methodist Hospital

Columbus, Ohio, 43214, United States
Riverwood Healthcare Center

Aitkin, Minnesota, 56431, United States
Rocky Mountain Cancer Centers-Lakewood

Lakewood, Colorado, 80228, United States
Rocky Mountain Cancer Centers-Longmont

Longmont, Colorado, 80501, United States
Rocky Mountain Cancer Centers-Penrose

Colorado Springs, Colorado, 80907, United States
Rocky Mountain Cancer Centers-Thornton

Thornton, Colorado, 80260, United States
Rush-Copley Healthcare Center

Yorkville, Illinois, 60560, United States
Rush-Copley Medical Center

Aurora, Illinois, 60504, United States
SIH Cancer Institute

Carterville, Illinois, 62918, United States
Saint Ann's Hospital

Westerville, Ohio, 43081, United States
Saint Anthony Hospital

Lakewood, Colorado, 80228, United States
Saint Anthony Regional Hospital

Carroll, Iowa, 51401, United States
Saint Charles Health System

Bend, Oregon, 97701, United States
Saint Charles Health System-Redmond

Redmond, Oregon, 97756, United States
Saint Clare Hospital

Lakewood, Washington, 98499, United States
Saint Elizabeth Hospital

Enumclaw, Washington, 98022, United States
Saint Elizabeth Regional Medical Center

Lincoln, Nebraska, 68510, United States
Saint Francis Cancer Center

Colorado Springs, Colorado, 80923, United States
Saint Francis Hospital

Federal Way, Washington, 98003, United States
Saint Francis Medical Center

Cape Girardeau, Missouri, 63703, United States
Saint Francis Regional Medical Center

Shakopee, Minnesota, 55379, United States
Saint John Macomb-Oakland Hospital

Warren, Michigan, 48093, United States
Saint John's Hospital - Healtheast

Maplewood, Minnesota, 55109, United States
Saint Joseph Hospital East

Lexington, Kentucky, 40509, United States
Saint Joseph London

London, Kentucky, 40741, United States
Saint Joseph Mercy Brighton

Brighton, Michigan, 48114, United States
Saint Joseph Mercy Canton

Canton, Michigan, 48188, United States
Saint Joseph Mercy Chelsea

Chelsea, Michigan, 48118, United States
Saint Joseph Mercy Hospital

Ann Arbor, Michigan, 48106, United States
Saint Joseph Mercy Oakland

Pontiac, Michigan, 48341, United States
Saint Joseph Radiation Oncology Resource Center

Lexington, Kentucky, 40504, United States
Saint Joseph Regional Cancer Center

Bryan, Texas, 77802, United States
Saint Joseph's/Candler - Bluffton Campus

Bluffton, South Carolina, 29910, United States
Saint Louis Cancer and Breast Institute-Ballwin

Ballwin, Missouri, 63011, United States
Saint Louis Cancer and Breast Institute-South City

St Louis, Missouri, 63109, United States
Saint Luke's Cancer Institute - Boise

Boise, Idaho, 83712, United States
Saint Luke's Cancer Institute - Fruitland

Fruitland, Idaho, 83619, United States
Saint Luke's Cancer Institute - Meridian

Meridian, Idaho, 83642, United States
Saint Luke's Cancer Institute - Nampa

Nampa, Idaho, 83687, United States
Saint Luke's Cancer Institute - Twin Falls

Twin Falls, Idaho, 83301, United States
Saint Luke's Hospital

Cedar Rapids, Iowa, 52402, United States
Saint Mary Corwin Medical Center

Pueblo, Colorado, 81004, United States
Saint Mary Mercy Hospital

Livonia, Michigan, 48154, United States
Saint Mary's Oncology/Hematology Associates of Marlette

Marlette, Michigan, 48453, United States
Saint Mary's Oncology/Hematology Associates of West Branch

West Branch, Michigan, 48661, United States
Saint Michael Cancer Center

Bremerton, Washington, 98310, United States
Saint Patrick Hospital - Community Hospital

Missoula, Montana, 59802, United States
Saint Rita's Medical Center

Lima, Ohio, 45801, United States
Sainte Genevieve County Memorial Hospital

Sainte Genevieve, Missouri, 63670, United States
Saints Mary and Elizabeth Hospital

Louisville, Kentucky, 40215, United States
Sanford Bismarck Medical Center

Bismarck, North Dakota, 58501, United States
Sanford Broadway Medical Center

Fargo, North Dakota, 58122, United States
Sanford Cancer Center Oncology Clinic

Sioux Falls, South Dakota, 57104, United States
Sanford Cancer Center Worthington

Worthington, Minnesota, 56187, United States
Sanford Joe Lueken Cancer Center

Bemidji, Minnesota, 56601, United States
Sanford Medical Center Fargo

Fargo, North Dakota, 58104, United States
Sanford Roger Maris Cancer Center

Fargo, North Dakota, 58122, United States
Sanford South University Medical Center

Fargo, North Dakota, 58103, United States
Sanford Thief River Falls Medical Center

Thief River Falls, Minnesota, 56701, United States
Sanford USD Medical Center - Sioux Falls

Sioux Falls, South Dakota, 57117-5134, United States
South Carolina Cancer Specialists PC

Hilton Head Island, South Carolina, 29926-3827, United States
Southeast Cancer Center

Cape Girardeau, Missouri, 63703, United States
Southern Illinois University School of Medicine

Springfield, Illinois, 62702, United States
Southern Ohio Medical Center

Portsmouth, Ohio, 45662, United States
Southpointe-Sanford Medical Center Fargo

Fargo, North Dakota, 58103, United States
Southwest Oncology PC

Durango, Colorado, 81301, United States
Sparrow Hospital

Lansing, Michigan, 48912, United States
Spectrum Health Reed City Hospital

Reed City, Michigan, 49677, United States
Spectrum Health at Butterworth Campus

Grand Rapids, Michigan, 49503, United States
Springfield Clinic

Springfield, Illinois, 62702, United States
Springfield Memorial Hospital

Springfield, Illinois, 62781, United States
Straub Clinic and Hospital

Honolulu, Hawaii, 96813, United States
Straub Medical Center - Kahului Clinic

Kahului, Hawaii, 96732, United States
Straub Pearlridge Clinic

‘Aiea, Hawaii, 96701, United States
Strecker Cancer Center-Belpre

Belpre, Ohio, 45714, United States
Suburban Hematology Oncology Associates - Snellville

Snellville, Georgia, 30078, United States
Swedish Cancer Institute-Edmonds

Edmonds, Washington, 98026, United States
Swedish Cancer Institute-Issaquah

Issaquah, Washington, 98029, United States
Swedish Medical Center-Ballard Campus

Seattle, Washington, 98107, United States
Swedish Medical Center-Cherry Hill

Seattle, Washington, 98122-5711, United States
Swedish Medical Center-First Hill

Seattle, Washington, 98122-4307, United States
The Cancer Center of Hawaii-Liliha

Honolulu, Hawaii, 96817, United States
The Cancer Center of Hawaii-Pali Momi

‘Aiea, Hawaii, 96701, United States
The Carle Foundation Hospital

Urbana, Illinois, 61801, United States
The Mark H Zangmeister Center

Columbus, Ohio, 43219, United States
The Queen's Medical Center - West Oahu

‘Ewa Beach, Hawaii, 96706, United States
The Radiation Oncology Center-Hilton Head/Bluffton

Hilton Head Island, South Carolina, 29926, United States
TriHealth Cancer Institute-Anderson

Cincinnati, Ohio, 45255, United States
TriHealth Cancer Institute-Westside

Cincinnati, Ohio, 45247, United States
Trinity Regional Medical Center

Fort Dodge, Iowa, 50501, United States
United Hospital

Saint Paul, Minnesota, 55102, United States
Unity Hospital

Fridley, Minnesota, 55432, United States
University Medical Center New Orleans

New Orleans, Louisiana, 70112, United States
University of Hawaii Cancer Center

Honolulu, Hawaii, 96813, United States
University of New Mexico Cancer Center

Albuquerque, New Mexico, 87102, United States
UofL Health Medical Center Northeast

Louisville, Kentucky, 40245, United States
Valley Radiation Oncology

Peru, Illinois, 61354, United States
Wake Forest Baptist Health - Wilkes Medical Center

Wilkesboro, North Carolina, 28659, United States
Wake Forest University Health Sciences

Winston-Salem, North Carolina, 27157, United States
Wake Forest University at Clemmons

Clemmons, North Carolina, 27012, United States
West Jefferson Medical Center

Marrero, Louisiana, 70072, United States
West Michigan Cancer Center

Kalamazoo, Michigan, 49007, United States
Western Illinois Cancer Treatment Center

Galesburg, Illinois, 61401, United States
Wilcox Memorial Hospital and Kauai Medical Clinic

Lihue, Hawaii, 96766, United States

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