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PTSD linked to blood vessel damage, study suggests

NCT ID NCT03778307

Knowledge-focused Sponsor: University of California, Los Angeles Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jul 24, 2026 · Updated 2 times

Summary

This completed study looked at 168 adults with a history of trauma to see if PTSD harms blood vessel function, which could raise heart disease risk. Participants completed behavioral tasks measuring fear and attention, and had their blood vessel health checked. The goal is to understand how PTSD might lead to heart problems, so at-risk people can be identified earlier.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help identify trauma survivors at higher risk for heart disease, enabling earlier prevention.
What could go wrong
This is an observational study, not a treatment trial. It cannot prove cause and effect, and results may not apply to all trauma survivors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

168 people

The number who actually took part.

Started

Nov 2019

Finished

Jun 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Trauma-exposed adults without a history of cardiovascular disease recruited from the community

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged 18+ years * History of exposure to a psychological trauma (e.g., natural disaster, physical assault) * Fluent in English * Willing to and capable of providing informed consent Additional Inclusion Criteria for the PTSD Group * Diagnosed with current PTSD (duration of at least 1 month) using the Clinician-Administered PTSD Scale for Diagnostic and Statistical Manual 5th Edition (DSM-5) (CAPS-5) at the diagnostic interview assessment Exclusion Criteria: * History of CVD (i.e., diagnosis of myocardial infarction, unstable angina, heart failure, peripheral artery disease, or stroke) * Deemed unable to comply with the protocol (either self-selected or by indicating during screening that could not complete all requested tasks) * Current bipolar disorder or psychotic disorder * Mild or more severe cognitive impairment \[Mini-Mental State Exam (MMSE)3 score ≤18\] * Current moderate or severe substance use disorder * Acute, unstable, or severe medical disorder or pregnancy * Deemed to need immediate psychiatric intervention (e.g., active suicidality) * Use of antipsychotic, mood stabilizer, antidepressant, or stimulant medication in the past 4 weeks * Daily benzodiazepine use in the past 2 weeks Additional Exclusion Criteria for the Trauma-Exposed Matched Control Group * Current or past diagnosis of any DSM-5 psychiatric disorder * CAPS-5 total score ≥25

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Conditions

The condition(s) this trial relates to.

injury post-traumatic stress disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Endothelial dysfunction PTSD Trauma

Contacts and locations

Locations

  • UCLA

    Los Angeles, California, 90095, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.