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Smoothie study reveals how protein type impacts your cells

NCT ID NCT07121010

Knowledge-focused Sponsor: University of Pittsburgh Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how animal-based and plant-based proteins change metabolism and immune signals in healthy adults. Twenty participants will drink three different protein smoothies on separate visits and give blood samples. Researchers want to see if adding leucine to plant protein makes the body react like it does to animal protein. The goal is to understand how protein source affects a key nutrient-sensing pathway linked to heart disease.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Animal-based protein smoothie, plant-based protein smoothie, and plant-based protein smoothie with added leucine
What this could lead to
If successful, this study could show that adding leucine to plant protein makes the body respond similarly to animal protein, potentially improving plant-based diets for metabolic health.
What could go wrong
This is a small, early-phase trial with only 20 healthy participants, so results may not apply to everyone. It measures short-term blood changes, not long-term health outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2026

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age 18-65 years 2. BMI 18.5-29.9 kg/m² 3. Generally healthy, without known chronic illness and/or treatment with chronic medications 4. Willing to comply with dietary restrictions and study procedures 5. Not currently following a prescribed or restrictive diet (for example, vegan, ketogenic or high-protein regimen) or regularly taking high-protein supplements Exclusion Criteria: 1. History of cardiovascular disease, diabetes, or autoimmune disorders 2. Active use of anti-inflammatory, immunomodulatory, or lipid-lowering medications 3. Renal or hepatic dysfunction 4. Pregnancy or breastfeeding 5. Allergies or intolerances to components of study meals. A list of the smoothie ingredients will be sent to the potential participant with the mailing of the consent form 6. Participation in another interventional study within the last 30 days

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Conditions

The condition(s) this trial relates to.

atherosclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiometabolic health

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • UPMC Montefiore - Clinical and Translational Research Center (CTRC)

    RECRUITING

    Pittsburgh, Pennsylvania, 15213, United States

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