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Which sedative is safer for ICU intubation? new study investigates

NCT ID NCT06750939

Knowledge-focused Sponsor: Kocaeli City Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study observes 128 critically ill ICU patients to see how two common sedatives—propofol and ketamine—affect the risk of severe drops in blood pressure or cardiac arrest during emergency intubation. Propofol can lower blood pressure, while ketamine may help maintain stability. The goal is to provide clearer guidance for doctors choosing induction agents in high-risk situations.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help doctors choose safer drugs for emergency intubation in critically ill patients, potentially reducing life-threatening drops in blood pressure or cardiac arrest.
What could go wrong
This is an observational study, not a controlled trial, so it can show associations but not prove cause and effect. Results may not apply to all ICU settings or patient types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 128 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2024

Expected to finish

Nov 2025

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients admitted to the intensive care unit (ICU) who undergo endotracheal intubation during their ICU stay will be included.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged over 18 years * Patients admitted to the intensive care unit (ICU) who undergo endotracheal intubation during their ICU stay will be included. Exclusion Criteria: * Patients who did not provide consent to participate in the study * Patients intubated due to cardiac arrest * Patients intubated outside the intensive care unit

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Conditions

The condition(s) this trial relates to.

cardiac arrest cardiogenic shock Shock

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anaesthetic complication cardiac Cardiovascular collapse Intubation complication

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Kocaeli City Hospital

    RECRUITING

    Köseköy, Kocaeli, 41060, Turkey (Türkiye)

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