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New study tests safer dosing of Heart-Stabilizing drug during breathing tube insertion

NCT ID NCT06327399

Symptom relief Sponsor: Kasr El Aini Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jul 10, 2026 · Updated 3 times

Summary

This study tested two methods of giving the drug dexmedetomidine to 70 adults during intubation (placing a breathing tube). One group received a slow infusion over 10 minutes, the other a quick bolus over 60 seconds. The goal was to see which method causes fewer changes in heart rate and blood pressure. Researchers also tracked any episodes of very slow heart rate or low blood pressure that needed rescue medication.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Dexmedetomidine
What this could lead to
If it works, this could point toward a safer way to give dexmedetomidine during intubation, reducing heart rate and blood pressure swings.
What could go wrong
This is a small, completed Phase 2 trial with only 70 participants. Results may not apply to all patients, and the drug can still cause slow heart rate or low blood pressure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

70 people

The number who actually took part.

Started

Apr 2024

Finished

Sep 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ASA I and II patients. * Mallampati grade I and II. Exclusion Criteria: * Patient refusal. * Morbid obesity. * Predicted difficult airway/unanticipated difficult intubation or laryngoscopic attempt lasting greater than 15 seconds or two attempts or more. * Patients with uncontrolled sepsis. * Pregnancy or breast feeding. * Patients with renal impairment i.e. SCr ≥ 1.5 * Any patient on regular intake of beta blockers or calcium channel blockers. * CNS disorders.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dexmedetomidine Intubation complication

Contacts and locations

Locations

  • Cairo University Hospitals

    Giza, Giza Governorate, 11562, Egypt

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