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Can a special toothbrush stop pneumonia in ICU patients?

NCT ID NCT07125495

Disease control Sponsor: Koç University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether using a suction toothbrush for oral care could reduce ventilator-associated pneumonia (VAP) in intubated ICU patients. 111 adults on breathing machines were randomly assigned to cleaning with distilled water or a chlorhexidine solution using the suction toothbrush. The goal was to see if this approach lowers infection risk by removing secretions better than standard care.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
suction toothbrush
What this could lead to
If effective, this simple oral care tool could lower pneumonia risk for patients on breathing machines in ICUs.
What could go wrong
This is a small, completed trial with no phase designation. Results may not apply to all ICU settings or patient groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

111 people

The number who actually took part.

Started

Feb 2025

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Patients * who aged over 18 years * who underwent orotracheal intubation after admission to the ICU, * who had no known pneumonia or diagnosis of pneumonia at the time of intubation, * who were intubated for more than 48 hours, * who had no microorganisms detected in the tracheal aspirate within the first 48 hours, * who had no lesions on the oral mucous membrane before intubation, * who had no known allergy to chlorhexidine were included in the study. Exclusion Criteria: Patients * who under 18 years of age, * those with a tracheostomy, * those were intubated for less than 48 hours, * those with microorganisms detected in their tracheal aspirate within the first 48 hours, * those who underwent reintubation, * those were pregnant, * those with lesions in the oral mucosa during intensive care admission, * those with bleeding coagulation disorders or thrombocytopenia, * those admitted to intensive care from an external institution while intubated, and those with a known chlorhexidine allergy were excluded from the study.

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Conditions

The condition(s) this trial relates to.

Infections infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Infection Intensive care (ICU) Intubation Intubation complication

Contacts and locations

Locations

  • Koç University hospital Intensive care unit

    Istanbul, 34010, Turkey (Türkiye)

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Other studies related to the condition(s) this trial covers.