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Propofol euphoria: how common is the 'High' during routine scope exams?

NCT ID NCT06602297

Knowledge-focused Sponsor: Northern Jiangsu People's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed study looked at nearly 1,000 patients having painless gastrointestinal endoscopy to find out how often propofol causes feelings of euphoria, how strong those feelings are, and how long they last. Researchers asked patients to rate their pleasure and mood changes after the procedure. The goal is to better understand propofol's potential for misuse or addictive behaviors.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
propofol
What this could lead to
If it succeeds, this could help doctors understand and manage the risk of propofol-related euphoria and potential addictive behaviors.
What could go wrong
This is a single-center, observational study that only measures feelings, not long-term addiction. Results may not apply to other settings or populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

986 people

The number who actually took part.

Started

Sep 2024

Finished

Jun 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult Participants with ASA I-II Proposed for Painless Gastrointestinal Endoscopy

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Proposed to perform painless GI endoscopy, and simple endoscopic maneuvers such as single small polyp clamping, performing HP examination, etc; * Gender is not limited; * 18 years old ≤ 80 years old; * ASA classification: I-II; * 18 kg/m2 \<BMI \<30 kg/m2; * Informed consent, voluntary participation in the trial, and informed consent signed by the subjects themselves. Exclusion Criteria: * adjudicated respiratory management difficulties; * History of substance abuse as well as drug use; * Participation in a clinical trial of another drug or device within 3 months prior to the screening period * Use of therapeutic drugs (e.g., benzodiazepines, opioid analgesics) by the subject within 3 months prior to the Screening Period for a variety of reasons (e.g., insomnia, pain, etc.) that may have an impact on the outcome of the trial, etc; * Allergy or contraindication to the study drug or components thereof; * Previous psychiatric or neurological disorders (e.g., schizophrenia, mania, bipolar disorder, psychosis, epilepsy, neuralgia, etc.) and a history of taking medications corresponding to the treatment of the corresponding psychiatric or neurological disorders (e.g., antidepressants, anxiolytics, convulsants, antiepileptic drugs, etc.); * Pregnant women; * Subjects with severe communication disorders due to severe hearing deterioration; * Refusal to participate in this study; * Those deemed unsuitable by the investigator.

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Conditions

The condition(s) this trial relates to.

Behavior, Addictive

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Addictive behaviors Propofol

Contacts and locations

Locations

  • Northern Jiangsu People's Hospital

    Yangzhou, Jiangsu, 225001, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.