Could probiotics ease tooth pain after root canal?
NCT ID NCT07270159
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether probiotics, a double antibiotic paste, or calcium hydroxide paste can reduce pain after root canal treatment in adults with severe tooth inflammation (irreversible pulpitis). 75 participants received one of the three pastes placed inside the tooth and reported their pain levels over a week. The goal was to find which works best for pain relief.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Probiotics, double antibiotic paste, and calcium hydroxide paste
- What this could lead to
- If probiotics work, this could point toward a more natural way to manage pain after root canal treatment.
- What could go wrong
- This is a small, completed trial with only 75 participants, so results may not apply to everyone. Probiotics may not reduce pain better than standard treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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75 people
The number who actually took part.
- Started
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Jun 2025
- Finished
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Nov 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 45 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Patients falling in ASA 1 category 2. Suffering from symptomatic irreversible pulpitis with range from moderate to severe. In addition to this patient should also have experienced lingering of pain. VAS score will be used to record pain. (Confirmed by clinical and radiographic signs) with or without apical periodontitis. 3. Multirooted teeth (Mandibular 1st and 2nd molars) 4. Age 18-45 year 5. Teeth with a Periapical Index (PAI) score of 1 -3, indicating a healthy periapical status or minimal changes in bone structure not necessarily associated with apical periodontitis, were included in this study. Exclusion Criteria: 1. Pregnant or lactating mothers 2. Subjects taking chronic pain medications within last 24 hrs. 3. Cracks, complex anatomy, pulp calcification
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Dow International Dental College
Karachi, Sindh, 12345, Pakistan
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