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Can a steroid injection before root canal silence Post-Procedure pain?

NCT ID NCT07755306

Symptom relief Sponsor: Ain Shams University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 10, 2026 · Last updated Aug 14, 2026 · Updated 2 times

Summary

This trial asks whether injecting dexamethasone, a steroid, before a root canal can reduce pain afterward. Adults with a painful, inflamed tooth will receive the injection either in the cheek or near the tooth, or just standard numbing. Pain levels will be tracked for three days to see if the steroid helps.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dexamethasone
What this could lead to
If effective, this could offer a simple, low-cost way to reduce pain after root canal treatment, potentially decreasing the need for painkillers.
What could go wrong
This is a small, early-stage trial, and results may not apply to all patients. Dexamethasone injections can cause local side effects like pain or swelling, and the benefit over standard care is not yet proven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

66 people

The number who actually took part.

Started

Mar 2024

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Both genders * Older than age of (18 to 60) years * Participants willing to commit for the entire period of the trial and agreed to sign the written consent after full explanation of the study * Having a mandibular molar tooth with vital pulp * These patients were also suffering from symptomatic irreversible pulpitis ,intermittent or continuous sharp pain that lasts longer after removal of the stimulus * Patients with moderate to severe symptoms VAS≥4 Exclusion Criteria: * Vulnerable group; pregnant females, mentally ill and diseased patientsetc.… * Patients irritable to local anesthesia * Patients who are supposed to take plain anesthesia * Use of analgesic or antibiotic within 6 hours before the visit * Absence of bleeding in the pulp chamber during cavity preparation * Severe periodontal disease b- Patients' randomization, allocation and blinding:

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Post operative pain, acute

Contacts and locations

Locations

  • Faculty of Dentistry Ain Shams University

    Cairo, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.