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Gut-Brain link: probiotic may slow memory decline in seniors

NCT ID NCT07165977

Symptom relief Sponsor: University of Social Sciences and Humanities, Warsaw Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 2 times

Summary

This study tests whether a daily probiotic supplement can improve memory and thinking in adults aged 50 and older. Over 6 months, participants take either the probiotic or a placebo for 3 months, then switch. Researchers measure memory tests, brain activity, and gut bacteria to see if diet and microbiome affect results.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Probiotic supplement (Bifidobacterium longum Rosell®-175 and Lactobacillus helveticus Rosell®-52)
What this could lead to
If it works, this could point toward a simple, safe way to slow age-related memory decline using a daily probiotic.
What could go wrong
This is a small, early-stage crossover study with 110 participants. The effect may be small or not last, and results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 110 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2024

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged 50 or older * Signed written Informed Consent Form * Score ≥28 on the Mini-Mental State Examination (MMSE) * A willingness and motivation to follow the study protocol Exclusion Criteria: * Regular use of prebiotics, antibiotics, or antifungal medications * Use of prebiotics, antibiotics, or antifungal medications within the past 3 months * Diagnosed neurological disorder * History of head injury with neurological consequences * Left-handedness

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cognitive aging Cognitive decline Memory decline

Contacts and locations

Locations

  • SWPS University

    Warsaw, Masovian Voivodeship, 03-815, Poland

More trials for these conditions

Other studies related to the condition(s) this trial covers.