Blood-derived gel may help preserve jawbone after tooth removal
NCT ID NCT03943680
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether a gel made from a patient's own blood (PRGF) can help preserve bone after a tooth extraction, compared to a standard cow-bone graft. Thirty adults who needed a tooth pulled and later a dental implant took part. Researchers measured bone changes with CT scans and looked at bone quality under a microscope four months later.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- PRGF (platelet-rich plasma) and bovine bone xenograft
- What this could lead to
- If PRGF works well, it could offer a simpler, natural way to preserve bone after tooth extraction, potentially reducing the need for animal-derived bone grafts.
- What could go wrong
- This is a small, completed study with only 30 participants, so results may not apply to everyone. PRGF may not maintain bone as well as the standard bone graft.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
30 people
The number who actually took part.
- Started
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Mar 2019
- Finished
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Oct 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 75 years
- Sex
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Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Upper or lower premolar or molar tooth in need of extraction and later restoration by dental implant. * Adjacent and opposing natural teeth present and healthy. * At least 3 mm from the tip of the dental root to the maxillary sinus or the inferior alveolar canal. Exclusion Criteria: * Active local infection. * Uncontrolled diabetes mellitus. * Long term (\>10 years) use of oral bisphosphonates. * Use of intravenous bisphosphonates. * Recent use (\<3 months) of antibiotics, antiinflammatories or analgesics drugs. * Pregnancy. * Smokers of more than 10 cigarettes per day. * Any oral pathology that needs to be treated before tooth extraction, particularly the presence of more than 25% of sites with bleeding on probing.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Facultad de Odontología
Granada, Granada, 18071, Spain
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a natural compound help preserve jawbone after tooth loss?