Blood DNA levels may signal pregnancy problems
NCT ID NCT01736826
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study measured the amount of free-floating DNA and nucleosomes in the blood of 137 women to see if these levels differ between those with pregnancy complications (like preeclampsia or blood clots) and healthy women (both pregnant and non-pregnant). The goal was to better understand these markers, not to treat or cure any condition. Results could help future research on detecting pregnancy risks.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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137 people
The number who actually took part.
- Start date
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Jun 2015
- Finished
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Dec 2017
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The study population includes three groups: Group P: 100 pregnant women with complications typical of placental vascular disease or venous thromboembolism. Group T1: 30 non-pregnant, healthy volunteers * The first 15 patients from group T1 will form group T1x. The latter group has two months of additional follow up. Group T2: 50 pregnant, healthy volunteers * The first 15 patients from group T2 will form group T2x. The latter group has 7 months of follow-up during pregnancy.
- Ages
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18 years and older
- Sex
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Female participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria for all patients: * The patient must have given her informed and signed consent * The patient must be insured or beneficiary of a health insurance plan Inclusion Criteria for patients in group P: * The patient is pregnant and has complications typical of placental vascular disease (preeclampsia, eclampsia, HELLP syndrome, retro-placental hematoma, in utero fetal death) or venous thromboembolism (deep vein thrombosis, pulmonary embolism) Inclusion Criteria for patients in group T1: * The patient is available for 3 months of follow-up * The patient is a non-pregnant healthy volunteer * No identifiable chronic pathologies * No history of neoplastic disease * No history of chronic infectious disease * No acute disease (such as benign infection), now or within the past two weeks Inclusion Criteria for patients in group T2: * The patient is available for 7 months of follow-up * The patient is pregnant, with no identifiable pregnancy complications * No identifiable chronic pathologies * No history of neoplastic disease * No history of chronic infectious disease * No acute disease (such as benign infection), now or within the past two weeks Exclusion Criteria for all patients: * The patient is participating in another study (with the exception of the following studies: PAPILLO-PMA (2013-A00538-37), ElastoMAP (2013-A01148-37), ElastoDéclenche (2014-A00828-39), LXRs (2009-A00968-49), Bakri (2013-A00914-41), OASIS 2 (2013-A00022-43)). * The patient is in an exclusion period determined by a previous study * The patient is under judicial protection, under tutorship or curatorship * The patient refuses to sign the consent * It is impossible to correctly inform the patient * The patient cannot read French * The patient is receiving hormonal ovarian stimulation in the context of medically assisted procreation * Impossible to perform venipuncture under good conditions * New complication or pathology during the study (except for pregnancy complications in group P) Exclusion Criteria for group P: * Twin or multiple pregnancy * The patient is participating in another study (with the exception of those mentioned in the exclusion criteria for all patients and the DG Postpartum study (2013-A00277-38) Exclusion Criteria for group T1: * The patient is pregnant * The patient is breast feeding * The patient has given birth within the last 3 months * Known history of chronic disease * History of treated neoplastic disease * Acute disease within the past two weeks (includes benign disease) Exclusion Criteria for group T2: * Pregnancy with complications * Known history of chronic disease * History of treated neoplastic disease * Acute disease within the past two weeks (includes benign disease) * Twin or multiple pregnancy
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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CHU de Nîmes - Hôpital Universitaire Carémeau
Nîmes, 30029, France
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Other studies related to the condition(s) this trial covers.
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