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Scientists track recovery in seniors after knee surgery to unlock secrets of resilience

NCT ID NCT04235309

Knowledge-focused Sponsor: Duke University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed study from Duke University looked at 297 older adults (60+) undergoing knee replacement surgery. Researchers measured physical activity, pain, thinking skills, and immune responses before and after surgery to understand what helps people recover well. The goal was to find markers of physical resilience, not to test any treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help doctors predict which older patients will recover well after surgery and who might need extra support.
What could go wrong
This is an observational study, not a treatment trial. It only measures recovery patterns and cannot guarantee any direct benefit to participants.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

297 people

The number who actually took part.

Started

Feb 2020

Finished

Oct 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Prospective observational study of n=250 adults aged 60 years and older undergoing elective total knee replacements with 6 months of follow-up.

Ages

60 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 60 years of age or older * Ability to speak English * Planned elective knee replacement orthopedic surgery lasting 2 or more hours and requiring overnight observation or inpatient stay * Community dwelling Exclusion Criteria: * Unable to ambulate independently, with or without assistive device * Known dementia or screening 3MS score \<=77 * Inmate of a correctional facility (i.e. prisoners) * Active non-skin cancer or medical treatment for non-skin cancer with 12 months (chemotherapy, radiation, immunotherapy, hormonal therapy) * Vision or hearing impairment that, after best accommodation, prevents reliable cognitive assessment (visual/hearing) and/or precludes telephone interviews (hearing)

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aging Resilience

Contacts and locations

Locations

  • Duke Regional Hospital

    Durham, North Carolina, 27704, United States

  • Duke University Hospital

    Durham, North Carolina, 27710, United States

  • Duke University Medical Center

    Durham, North Carolina, 27710, United States

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