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Could a simple ventilation tweak calm lung surgery inflammation?

NCT ID NCT07749456

Knowledge-focused Sponsor: University of Nis Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This trial asks whether allowing carbon dioxide levels to rise slightly during one-lung surgery can dampen the body's inflammatory response. Forty adults having elective lung surgery are randomly assigned to either standard ventilation or permissive hypercapnia. Researchers measure inflammation markers in fluid from the lungs and in blood before and after the procedure, and also compare two ventilation modes. The goal is to understand whether this approach might reduce surgery-related lung inflammation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
permissive hypercapnia (allowing higher carbon dioxide levels during ventilation)
What this could lead to
If it works, this could point toward a way to reduce lung inflammation during surgery, potentially improving recovery after lung operations.
What could go wrong
This is a small, early-stage study with only 40 patients, so results may not apply broadly. The intervention involves deliberately raising carbon dioxide levels, which carries risks like increased pressure in the skull or strain on the heart.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

40 people

The number who actually took part.

Started

Jun 2015

Finished

Feb 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Eligible participants were aged 18-85 years, * classified as American Society of Anesthesiologists (ASA) physical status I-III, --scheduled for procedures expected to last at least 60 minutes, with anticipated OLV for the the majority of the intraoperative period. Exclusion Criteria: * body mass index (BMI) \> 35 kg/m2; * impaired pulmonary function (vital capacity of forced expiratory volume in 1 second (FEV1) \< 50% of predicted values); * chronic infection; * intracranial hypertension; * prior intracranial hemorrhage; * presence of active extrapulmonary malignancy; * chronic pulmonary diseases (including chronic pneumonia, pneumoconiosis and silicosis); * pulmonary hypertension; * severe chronic obstructive pulmonary disease (COPD) with chronic hypercapnia; * patients undergoing bilobectomy or pneumonectomy

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Thoracic surgery

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