Could a simpler nerve block keep blood sugar steady after lung surgery?
NCT ID NCT07754916
First seen Aug 10, 2026 · Last updated Aug 13, 2026 · Updated 3 times
Summary
This trial tests whether one type of nerve block (intercostal) is as good as another (paravertebral) for controlling pain and keeping blood sugar levels stable in the first two days after minimally invasive lung surgery. The study involves 64 adults aged 18-70 who are scheduled for video-assisted lung resection. Participants will receive one of the two blocks with a long-acting local anesthetic, and researchers will measure blood sugar variability, pain scores, and recovery quality to see if the simpler block works just as well.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- liposomal bupivacaine
- What this could lead to
- If successful, this could show that a simpler nerve block provides equal pain control and blood sugar stability after lung surgery, potentially improving recovery and reducing complications.
- What could go wrong
- This is a small, early-stage trial, and the results may not apply to all patients. The non-inferiority design means it can only show the simpler block is not worse, not that it is better.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 64 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Aug 2026
An estimate. Start dates often move.
- Expected to finish
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Feb 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Aged 18-70 years, with American Society of Anesthesiologists (ASA) physical status I-III, scheduled for uniportal or multiportal video-assisted thoracoscopic (VATS) minimally invasive pulmonary resection under general anesthesia. 2. Planned to receive liposomal bupivacaine regional block analgesia under direct thoracoscopic visualization. 3. Body mass index (BMI) 18-30 kg/m². 4. Willing and able to cooperate with the study procedures and provide written informed consent. Exclusion Criteria: 1. Regularly taking beta-blockers (for ≥2 weeks) or long-term use of high-dose glucocorticoids (prednisone ≥20 mg/day for \>2 weeks). 2. Known history of diabetes mellitus, or regular use of glucose-lowering agents (oral agents or insulin) before surgery. 3. Planned postoperative admission to the intensive care unit (ICU). 4. Concurrent severe cardiac (New York Heart Association class III or higher), hepatic (e.g., cirrhosis), or renal insufficiency (glomerular filtration rate \<30 mL/min/1.73 m²), or neuropsychiatric disorders. 5. Contraindications to regional block or to any study medication, including but not limited to infection or tumor invasion at the puncture site, coagulation disorders, or allergy to any drug used in the study. 6. Alcohol dependence: meeting the DSM-5 criteria for severe alcohol use disorder (AUD), or clinically judged as alcohol dependence (regardless of liver function status). 7. Pregnancy or lactation (for men and women of childbearing potential, effective contraception is required until 3 months after surgery, and donation of sperm or eggs is prohibited). 8. Participation in another interventional drug trial. 9. Regular use of analgesics for acute or chronic pain within 2 weeks before surgery. 10. Concurrent severe infection. 11. Prior ipsilateral intrathoracic surgery or severe pleural adhesions (estimated to preclude successful thoracoscopic visualization and completion of the block). 12. Psychiatric or cognitive disorders that would impair the ability to cooperate with postoperative follow-up. 13. Any other condition that, in the investigator's judgment, would make the patient unsuitable for participation in the trial (for medical or safety reasons).
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Department of Anesthesiology, Xiangya Hospital, Central South University
Changsha, Hunan, 410000, China
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