Could a simple ventilation tweak calm lung surgery inflammation?

NCT ID NCT07749456

Completed Knowledge-focused Sponsor: University of Nis Source: ClinicalTrials.gov ↗

First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This trial asks whether allowing carbon dioxide levels to rise slightly during one-lung surgery can dampen the body's inflammatory response. Forty adults having elective lung surgery are randomly assigned to either standard ventilation or permissive hypercapnia. Researchers measure inflammation markers in fluid from the lungs and in blood before and after the procedure, and also compare two ventilation modes. The goal is to understand whether this approach might reduce surgery-related lung inflammation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: permissive hypercapnia (allowing higher carbon dioxide levels during ventilation)
What this could lead to: If it works, this could point toward a way to reduce lung inflammation during surgery, potentially improving recovery after lung operations.
What could go wrong: This is a small, early-stage study with only 40 patients, so results may not apply broadly. The intervention involves deliberately raising carbon dioxide levels, which carries risks like increased pressure in the skull or strain on the heart.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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