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Does losing your appendix change how gut bugs bounce back after colonoscopy?

NCT ID NCT07478029

Knowledge-focused Sponsor: Huaping Xie Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how a common bowel-cleansing drink (PEG) used before colonoscopy changes the gut bacteria in people who have had their appendix removed. Researchers will compare these changes to those in people with an intact appendix. The goal is to understand if the appendix plays a role in helping gut bacteria recover after colonoscopy.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Polyethylene glycol (PEG) laxatives
What this could lead to
If successful, this study could reveal whether the appendix helps restore gut bacteria after colonoscopy, and whether its removal affects long-term gut health.
What could go wrong
This is a very small, early-stage observational study with only 10 participants. It does not test a treatment, so results may not lead to direct health changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 10 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2024

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The research subjects were adult patients from the Department of Gastroenterology of Tongji Hospital in Wuhan, China, who were scheduled to undergo colonoscopy. Participants were recruited continuously from the outpatient department and voluntarily joined after signing a written informed consent form. The participants were divided into two cohorts based on their history of appendectomy: individuals with a history of appendectomy (appendectomy group) and those without an appendectomy (normal group). All participants received routine bowel preparation using polyethylene glycol and provided fecal samples regularly within 6 months. No experimental interventions were conducted.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged 18-75 years. * Scheduled to undergo colonoscopy. * Generally healthy without major organ diseases. 1. For appendectomy group: history of appendectomy or right hemicolectomy (including appendectomy). 2. For control group: no history of appendectomy or right hemicolectomy. Exclusion Criteria: * Allergy or intolerance to PEG laxatives. * Pregnant or lactating women. * Mental disorders. * Use of antibiotics within 6 months prior to study enrollment. 1. Contraindications to colonoscopy (e.g., severe cardiopulmonary insufficiency). 2. For control group only: presence of organic diseases.

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Conditions

The condition(s) this trial relates to.

appendicitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Appendicitis Appendicitis acute

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Department of Gastroenterology Tongji Hospital, Tongji Medical college, Huazhong University of Science and technology

    RECRUITING

    Wuhan, Hubei, 430030, China

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