Parathyroid surgery may boost mobility in seniors
NCT ID NCT07103876
First seen Jun 27, 2026 · Last updated Sep 16, 2026 · Updated 2 times
Summary
This study looks at whether removing the parathyroid gland can improve physical function and mobility in adults aged 60 and older with primary hyperparathyroidism. Researchers will track changes in walking, strength, and daily activity before and after surgery, and analyze blood samples for clues. The goal is to gather evidence that could guide future treatments and potentially expand the use of this surgery for older patients.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- parathyroidectomy (surgical removal of the parathyroid gland)
- What this could lead to
- If successful, this could show that parathyroid surgery improves mobility and quality of life in older adults, potentially expanding who might benefit from the procedure.
- What could go wrong
- This is an observational study, not a controlled trial, so it cannot prove cause and effect. It is also small (80 people) and early-stage, so results may not apply to everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 80 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Aug 2025
- Expected to finish
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Mar 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
This study will enroll adults aged 60 years and older with a confirmed biochemical diagnosis of hypercalcemic primary hyperparathyroidism (PHPT) who are scheduled to undergo parathyroidectomy at UF Health. Eligible participants must be able and willing to provide informed consent and complete all study procedures, including pre- and post-operative physical assessments and blood draws.
- Ages
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60 to 100 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion: * Age ≥ 60 years; * Biochemical diagnosis of hypercalcemic (corrected serum calcium \>10.2 mg/dL or ionized serum calcium \>1.31 mmol/dL or 5.2 mg/dL on at least one serum sample) primary hyperparathyroidism as determined by board-certified endocrinologist or endocrine surgeon; * Undergoing parathyroidectomy at UF Health; * Willing and able to give informed consent. Exclusion: * Failure to provide informed consent; * Biochemical diagnosis of eucalcemic primary hyperparathyroidism (corrected serum calcium ≤10.2 mg/dL or ionized serum calcium ≤1.31 mmol/dL or 5.2 mg/dL on at least one serum sample); * Elected not to undergo parathyroidectomy at UF Health; * Major surgery as deemed by principal investigator or hip/knee replacement in the past 6 months; * Fractures to the hands, arms or legs within the last 6 months; * Traumatic accident (i.e. motor vehicle collision, fall from elevation, etc.) resulting in orthopedic trauma or requiring prolonged immobilization (\>2 weeks) within the last 6 months; * Blood transfusion within the past 3 months; * Self-reported myocardial infarction, cerebrovascular accident, or unstable angina within the past 6 months; * NYHA Class 3 or 4 congestive heart failure; * Major psychiatric disorder; * Cancer requiring treatment in the past 1 year (including metastatic cancer), except for locally treated non-melanoma skin cancers or cancers that have clearly been cured or in the opinion of the investigator carry an excellent prognosis (e.g., Stage 1 cervical cancer); * Renal failure requiring hemodialysis or peritoneal dialysis * Use of bone-modifying therapies (alendronate \[Fosamax\], zoledronic acid \[Reclast\], denosumab \[Prolia or Xgeva\], or romosozumab \[Evenity\]) within 1 month of planned surgery * Planning to permanently leave the area within 3 months of parathyroidectomy; * Vision or hearing impairment - defined as unable to read or listen/follow instructions despite the use of maximal assistive devices (i.e. contact lenses, glasses, hearing aids, etc.) * Participating in another clinical trial or has received an investigational product within 30 days prior to screening/enrollment.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The study's own enquiry address
This study publishes an address for enquiries. See it below .
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Show contact details
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Genom att skicka in godkänner du våra Användarvillkor
Locations
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Clinical and Translational Research Building
RECRUITINGGainesville, Florida, 32610, United States
Contact Email: •••••@•••••
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