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Glowing glands: camera light may guide parathyroid surgery when scans fail

NCT ID NCT07812649

Symptom relief Sponsor: The Cleveland Clinic Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 10, 2026 · Last updated Sep 11, 2026 · Updated 1 time

Summary

Primary hyperparathyroidism happens when one or more parathyroid glands make too much hormone, and surgery to remove the overactive gland is the only cure. When standard imaging cannot show exactly where the gland is, surgeons have a harder time finding it during the operation. This trial randomly assigns 80 patients to have parathyroid surgery with or without a near-infrared autofluorescence camera, which makes parathyroid tissue glow. Researchers compare how long it takes to find the gland, whether the surgery cures the condition, and how many frozen section tests are needed.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
A near-infrared autofluorescence (NIRAF) camera used during parathyroid surgery to help identify abnormal glands
What this could lead to
If it helps, surgeons could find overactive parathyroid glands faster and more reliably, which may improve cure rates for people whose scans before surgery fail to locate the problem gland.
What could go wrong
The trial is small, with 80 participants, and the camera is already used in some surgeries, so the benefit may turn out to be modest. Surgery still carries risks such as bleeding, infection, and damage to nearby structures.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2026

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosed with primary hyperparathyroidism * Undergoing bilateral neck exploration * Will under go only parathyroidectomy surgery Exclusion Criteria: * Diagnosed with secondary or tertiary hyperparathyroidism * Undergoing focal PG exploration * Will undergo concomitant surgery (total thyroidectomy, thyroid lobectomy)

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Conditions

The condition(s) this trial relates to.

primary hyperparathyroidism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Primary hyperparathyroidism

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Cleveland Clinic

    RECRUITING

    Cleveland, Ohio, 44195, United States

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