A gland transplant that could end a lifetime of calcium shots?
NCT ID NCT05114980
First seen Aug 21, 2026 · Last updated Aug 21, 2026
Summary
This trial tests whether transplanting parathyroid glands from a donor can help people with severe hypoparathyroidism—a condition where the body can't regulate calcium, often after neck surgery. Participants are adults aged 18-80 who have had the condition for at least a year and still need IV calcium despite medical treatment. The study will see if the transplanted glands produce parathyroid hormone and reduce the need for calcium supplements, while also monitoring for side effects from immunosuppression.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Parathyroid allotransplantation (transplant of donor parathyroid glands)
- What this could lead to
- If successful, this could offer a lasting treatment—or even a cure—for people with severe hypoparathyroidism who don't respond to standard therapy.
- What could go wrong
- This is an early, experimental procedure performed at only a few centers worldwide. Risks include transplant rejection, complications from immunosuppression, and the possibility that the transplanted glands may not function long-term.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Expected to start
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Jul 2027
An estimate. Start dates often move.
- Expected to finish
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Jan 2030
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Individual diagnosed with hypocalcemia secondary to 1. Hypoparathyroidism: 1. Prior anterior cervical neck surgery resulting in hypoparathyroidism 2. Congenital absence or malformation of parathyroid glands during development 2. Presence of hypoparathyroidism for at least one year 3. Failure of medical treatment for hypocalcemia, including need for IV calcium, with negative impact on quality of life and daily function 4. Age 18-80 years 5. Lives in the greater Birmingham region for the duration of the trial 6. Fluent in the English Language 7. Willing to comply with screening, protocol and all required procedures Exclusion Criteria: 1. Any active malignancy, except non-melanoma skin cancer 2. Dependence on nursing home or other long-term care provider 3. History of ischemic cardiomyopathy with ejection fraction \<20%, uncontrolled diabetes mellitus (Hgb A1c \>10), thrombophilia or other clotting or bleeding disorders, significant heart, liver, kidney or central nervous system disease 4. History of significant psychiatric illness 5. Severe osteoporosis 6. Allergy, hypersensitivity, or intolerance of expected immunosuppressive agents (i.e. Thymoglobulin®, tacrolimus, etc.) 7. Documented history of gross non-adherence to medical therapies 8. Significant functional/cognitive impairment without reliable caregiver 9. Presence of active documented systemic infection or recent systemic infection within the past 3 months 10. Seropositivity for HIV, HBV core antibody or antigen, HCV, HTLV-1 11. Current smoker (smoking cessation must have occurred 3 months prior to enrollment) 12. Chemical and/or alcohol dependency or abuse 13. Psychosocial problems (including alcoholism, drug abuse, documented behavioral disorders) 14. Resources deemed inadequate to support necessary post-transplant care
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of Alabama at Birmingham
Birmingham, Alabama, 35294, United States
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Other studies related to the condition(s) this trial covers.
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