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Brain oxygen drops may predict confusion after emergency surgery in seniors

NCT ID NCT03107260

Knowledge-focused Sponsor: Centre Hospitalier Universitaire, Amiens Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at 181 elderly patients (65 and older) having emergency non-heart, non-lung surgery. Researchers measured brain oxygen levels during surgery and checked for confusion or memory problems (called postoperative cognitive dysfunction) up to 72 hours later. The goal was to see if drops in brain oxygen are linked to these thinking problems. The findings could help doctors monitor and potentially reduce cognitive risks in older surgical patients.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If a clear link is found, it could help doctors monitor brain oxygen during surgery to reduce the risk of confusion or memory loss afterward.
What could go wrong
This is a completed observational study, not a treatment trial. It only looks for a relationship, so it cannot prove that changing oxygen levels would prevent cognitive issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

181 people

The number who actually took part.

Started

Jan 2016

Finished

Aug 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 65 years * Non-cardiac, thoracic and vascular emergency surgery * Surgery under general anesthesia * ASA I, II or III * Simple information without consent * Patient affiliated to social security Exclusion Criteria: * Inability to understand * Patient under tutelage, or curatorship or deprived of public right * ASA IV * History of severe dementia MMSE \<20 * Personal or familial history of malignant hyperthermia * History of allergy or hypersensitivity to anesthetic products used * Contra-indication to Cisatracurium®: myasthenia gravis * Contra-indication to Sevoflurane® * Contra-indication to local anesthetics * Indication of use of a Ketamine®-type hypnotic (modification of the BIS) * Indication of use of nitrous oxide * History of cranial trauma * Neuromuscular pathology * Spinal anesthesia * Cardiac, thoracic or vascular surgery * Surgery not performed in emergency * Neurochirugia in the context of cranial trauma * Any surgery that does not allow the use of the NIRS (impossibility of positioning of the electrodes by the location of the surgical field).

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction Emergencies

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cerebral saturation Cognitive impairment Emergencies

Contacts and locations

Locations

  • CHU Amiens Picardie

    Amiens, Picardie, 80054, France

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