New orexin mimic could wake up sleep disorder treatment

NCT ID NCT06752668

Recruiting now Symptom relief Sponsor: Centessa Pharmaceuticals (UK) Limited Source: ClinicalTrials.gov ↗

First seen Oct 31, 2025 · Last updated May 23, 2026 · Updated 24 times

Summary

This study tests a new drug called ORX750 (cleminorexton) that mimics a natural brain protein, orexin, which helps keep people awake. It is for adults with narcolepsy type 1, type 2, or idiopathic hypersomnia who struggle with severe daytime sleepiness. The goal is to see if the drug is safe and can reduce sleepiness and improve daily functioning.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Atlanta, Georgia
RECRUITING

Atlanta, Georgia, 30281, United States
Atlanta, Georgia
RECRUITING

Atlanta, Georgia, 30328, United States
Auburn, Alabama
RECRUITING

Auburn, Alabama, 36832, United States
Austin, Texas
RECRUITING

Austin, Texas, 78731, United States
Bologna, Italy
RECRUITING

Bologna, 40139, Italy
Brandon, Florida
RECRUITING

Brandon, Florida, 33511, United States
Chandler, Arizona
RECRUITING

Chandler, Arizona, 85224, United States
Cincinnati, Ohio
RECRUITING

Cincinnati, Ohio, 45245, United States
Cleveland, OH
RECRUITING

Cleveland, Ohio, 44106, United States
Columbia, South Carolina
RECRUITING

Columbia, South Carolina, 29201, United States
Denver, North Carolina
RECRUITING

Denver, North Carolina, 28037, United States
Dublin, Ohio
RECRUITING

Dublin, Ohio, 43017, United States
El Paso, TX
RECRUITING

El Paso, Texas, 79912, United States
Henderson, Nevada
RECRUITING

Henderson, Nevada, 89052, United States
Huntersville, North Carolina
RECRUITING

Huntersville, North Carolina, 28078, United States
Leon, France
RECRUITING

Léon, Bordeaux, 33000, France
Long Beach, California
RECRUITING

Long Beach, California, 90805, United States
Madrid, Spain
RECRUITING

Madrid, 28036, Spain
Madrid, Spain
RECRUITING

Madrid, 28043, Spain
Miami, Florida
RECRUITING

Miami, Florida, 33155, United States
Miami, Florida
RECRUITING

Miami, Florida, 33176, United States
New Orleans, Louisiana
RECRUITING

New Orleans, Louisiana, 70127, United States
Newton, Massachusetts
RECRUITING

Newton, Massachusetts, 02459, United States
North Charleston, South Carolina
RECRUITING

North Charleston, South Carolina, 29406, United States
Orlando, FL
RECRUITING

Orlando, Florida, 32807, United States
Pozzilli, Italy
RECRUITING

Pozzilli, 86077, Italy
Riverdale, Georgia
RECRUITING

Riverdale, Georgia, 30274, United States
San Antonio, Texas
RECRUITING

San Antonio, Texas, 78229, United States
Santa Ana, California
RECRUITING

Santa Ana, California, 92705, United States
Scottsdale, Arizona
RECRUITING

Scottsdale, Arizona, 85253, United States
Southfield, Michigan
RECRUITING

Southfield, Michigan, 48075, United States
Sterling Heights, Michigan
RECRUITING

Sterling Heights, Michigan, 48314, United States
Toronto, Ontario
RECRUITING

Toronto, Ontario, M5S 3A3, Canada
Verona, Italy
RECRUITING

Verona, 37134, Italy
Vitoria-Gasteiz, Spain
RECRUITING

Vitoria-Gasteiz, 01009, Spain
Willow Grove, Pennsylvania
RECRUITING

Willow Grove, Pennsylvania, 19090, United States
Winter Park, Florida
RECRUITING

Winter Park, Florida, 32789, United States

Conditions

Explore the condition pages connected to this study.

IDIOPATHIC HYPERSOMNIA NARCOLEPSY TYPE 1 NARCOLEPSY TYPE 2