Centessa Pharmaceuticals (uk) Limited

This study looks at the long-term safety and effects of a drug called ORX750 in people with narcolepsy (types 1 and 2) or idiopathic hypersomnia. About 90 participants who finished a previous ORX750 trial will take the drug openly for an extended period. Researchers will monitor …

This early-stage study tests a new drug called ORX142 in healthy adults and older adults to see if it is safe and how the body processes it. The study also checks how the drug works in people who have been kept awake on purpose. The goal is to gather information for future resear…

This study tests a new drug called ORX750 (cleminorexton) that mimics a natural brain protein, orexin, which helps keep people awake. It is for adults with narcolepsy type 1, type 2, or idiopathic hypersomnia who struggle with severe daytime sleepiness. The goal is to see if the …

This early-stage study is testing a new drug called ORX489 in healthy adults to see if it is safe and how the body handles it. Researchers will give single and multiple doses, and also check the effect of food. About 212 healthy volunteers aged 18 to 60 will take part. This study…