Blood pressure meds may do more harm than good for frail seniors
NCT ID NCT05047731
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at whether it is safe to reduce blood pressure medication in frail older adults living in long-term care. Researchers enrolled 522 residents with low blood pressure and tested a gradual medication reduction plan. The goal was to see if this approach could lower the risk of falls, confusion, and other harms without increasing heart problems or death.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
522 people
The number who actually took part.
- Started
-
Sep 2021
- Finished
-
Nov 2025
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
70 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * ≥2 diagnoses (dx) of hypertension from either a community practitioner or/and from a hospital admission. * On ≥1 oral antihypertensive medication (requires a dispensation in the preceeding 15 days). * Average recorded systolic BP of \<135 mmHg. Exclusion Criteria: * ≥2 community dx of congestive heart failure, ≥1 dx of in hospital congestive heart failure, ≥1 dx of emergency visit of congestive heart failure, dx of congestive heart failure in RAI-MDS 2.0, or prescription of furosemide in the last 15 days. * The resident's only antihypertensive prescribed is a beta blocker. * The resident's only antihypertensive prescribed is a calcium channel blocker and the resident has ≥1 health system encounters with a diagnosis of angina. * The resident's only antihypertensive prescribed is an alpha blocker. * Admitted to the hospital at the time of randomization; or opted out of the trial by the resident, their family, their physician, or the facility.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Frailty are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Multiple long-term care facilities
Multiple Locations, Alberta, Canada
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Inflatable leg cuffs tested as a Two-for-One therapy for high blood pressure and erectile dysfunction
- Can olive oil and exercise keep older adults on their feet?
- Can nurses and home monitors tame high blood pressure?
- Can a Hands-On reflex therapy steady an older Person's stance?
- Can immune aging blood tests predict which older IBD patients thrive on advanced therapies?
- Can pressing six points on the body help older adults sleep?