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Online prehab program aims to boost strength in liver transplant patients

NCT ID NCT05899231

Disease control Sponsor: University of Alberta Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a 12-week online program of exercise, nutrition advice, and behavioral support can improve physical function in adults with cirrhosis who are waiting for a liver transplant. About 177 participants from six Canadian transplant centers will be randomly assigned to either the online program or usual care. The main goal is to see if the program helps patients become less frail and better prepared for surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 177 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2023

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: ≥18 years old with cirrhosis (confirmed with transient elastography by FibroScan, histology, or imaging-based assessment with compatible clinical picture), referred for transplant and are assessed to have a high likelihood of being listed according to a preliminary review by hepatologist or are already listed for LT, are pre-frail or frail on the liver frailty index (LFI) or (added August 30, 2024) pre-frail or frail on the TeLeFI (prefrail LFI 3.2-4.3 and frail LFI ≥4.4), have English or French language proficiency, and own an internet-connected device. Exclusion Criteria: * Listed for living related donor transplantation with expected time on the wait list \<12 weeks, or model for end-stage liver disease (MELD-Na) Score \>26 (Justification: time to transplant is very short) * Robust status on frailty testing (LFI 0-3.1) (Justification: unlikely to see benefit) * Unable to provide informed consent * Presence of a clinical condition that makes the intervention unsafe or infeasible (e.g. unable to follow instruction) or unsafe environment for virtual participation * Life expectancy less than 6 months, compassionate care (clinician judgment) (Justification: unlikely to see benefit) * Recent variceal bleed or history of varices not on adequate prophylaxis (Justification: acute exercise increases portal pressure * Transplant indication is cholangiocarcinoma.

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Conditions

The condition(s) this trial relates to.

cirrhosis of liver Frailty liver disorder Malnutrition Motor Activity Sarcopenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cirrhosis, liver Liver disease Liver transplant surgery

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    6 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Foothills Medical Centre

    RECRUITING

    Calgary, Alberta, T2N 2T9, Canada

  • Gordon and Leslie Diamond Health Care Centre

    RECRUITING

    Vancouver, British Columbia, V5Z 1M9, Canada

  • Kaye Edmonton Clinic

    RECRUITING

    Edmonton, Alberta, T6G1Z1, Canada

  • London Health Sciences Centre

    RECRUITING

    London, Ontario, N6A 5W9, Canada

  • McGill University Health Centre

    RECRUITING

    Montreal, Quebec, H4A3J1, Canada

  • Toronto General Hospital - Ajmera Transplant Centre

    RECRUITING

    Toronto, Ontario, M5G 0A3, Canada

More trials for these conditions

Other studies related to the condition(s) this trial covers.