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One more hour on the ventilator could save lives, new trial hopes to prove

NCT ID NCT07324460

Knowledge-focused Sponsor: Hospital do Coracao Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether giving patients one extra hour of breathing support from a ventilator, after they pass a breathing test, helps them stay off the machine for good. About 4,000 ICU adults who have been on a ventilator for more than 72 hours will be randomly assigned to either immediate removal or one more hour of support. The goal is to see if this simple change reduces the chance of needing the ventilator again or dying within a week.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
one-hour positive pressure ventilation
What this could lead to
If it works, this could lead to a simple change in ICU practice that reduces the need for re-intubation and improves patient outcomes.
What could go wrong
This is an early-stage trial with no phase, and the intervention is a minor timing change, so the benefit may be small or not exist. Results may not apply to all ICU patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 4,000 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Feb 2026

An estimate. Start dates often move.

Expected to finish

Feb 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged \> 18 years. * Admitted to the intensive care unit (surgical or medical). * With endotracheal intubation. * Mechanical ventilation for more than 72 hours. * Who underwent successful spontaneous breathing trial (according to the study protocol) and is considered able to be extubated. Exclusion Criteria: * Patients unable to obey commands. * With non-planned extubation. * Neuromuscular disease and cervical spinal cord injury. * Tracheostomy. * Contraindication for cardiopulmonary resuscitation or reintubation. * Terminal extubation. * Lack of informed consent. * Previously included in the trial.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Airway extubation Extubation failure Weaning mechanical ventilation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

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