Chew on this: Mouth-and-Mind training may boost brain and bite
NCT ID NCT07733726
First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time
Summary
This trial tests a program that pairs oral motor exercises (like tongue and lip strengthening) with cognitive tasks (like memory or attention games) in adults aged 50 and older who have oral frailty and mild thinking problems. The goal is to see if doing both at the same time can improve chewing, swallowing, and cognitive function. Participants will train once a week for 32 weeks and have checkups halfway and at the end.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- a program combining oral motor exercises and cognitive tasks
- What this could lead to
- If it works, this could point toward a simple, non-drug way to improve both chewing/swallowing and thinking skills in older adults.
- What could go wrong
- This is a small feasibility study, so it may not prove effectiveness. The training is time-intensive (once a week for 32 weeks), and results may not apply to all older adults.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 66 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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May 2026
- Expected to finish
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Jun 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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50 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Adults aged 50 years or above; 2. Cantonese speaking; 3. Having oral frailty, which is defined as having at least two of the following components by Oral Frailty Five-item Checklist (OF-5): (i) Natural teeth fewer than 20, (ii) Have any difficulties eating tough foods now compared with 6 months ago; (iii) Have choked on tea or soup recently; (iv) Often experience having a dry mouth, and (v) Oral diadochokinetic /ta/ sound \<6.0 times/second; 4. Having subjective cognitive decline (SCD), which refers to self-reported experience of worsening or more frequent confusion or memory loss in the past 12 month, or having been diagnosed with mild or moderate cognitive impairment; defined as a score of 0.5, 1, or 2 on Clinical Dementia Rating (C.D.R) scale; 5. Living independently or with partial assistance, defined as a score of Modified Barthel Index score greater than 60 out of 100; 6. Right-handed person to minimize variability in cortical activation patterns during fNIRS measurement; 7. Can understand the purpose and contents of this project and could give written consent. Exclusion Criteria: 1. Have attended the dental clinics for dental treatment or received orofacial myofunctional therapy (OMT), involving doing certain oral exercises with cheeks, tongue, or lips in previous 6 months; 2. Have received other cognitive training in previous 6 month; 3. Have impaired vision or hearing capacity that cannot understand the training instructions; 4. Have a diagnosis of a neurological or psychiatric condition that could affect cognitive function; 5. Have terminal illness, Temporomandibular joint dysfunction (TMJ) disorders; Sjogren's (SHOW-grins) syndrome; 6. Have undergone glossectomy surgery; 7. have been taking drugs that affect cognitive function (e.g. Benzodiazepines, antidepressants, central nervous drugs).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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The Hong Kong Polytechnic University
Kowloon, Hong Kong
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